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ClinicalTrials.gov 22 recruiting now official registry

Pre Diabetes clinical trials

22 of 60 indexed Pre Diabetes trials are currently recruiting.

60 US clinical trials · 22 currently recruiting

Pre Diabetes is the subject of 60 registered US clinical trials on ClinicalTrials.gov, 22 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Clinical Nutrition Research Center, Illinois Institute of Technology, running 4 of these trials.

The research picture

Pre Diabetes has 60 registered US clinical trials, 22 of them open to new participants right now, about 37% of the total.

22
recruiting participants now
37%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
4
top sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology
Phase 13Phase 21Phase 31Phase 43

Active & Recent Trials

60 total, page 1 of 2

RECRUITING 2,000 participants

Glycemic Metrics and Patterns in People With and Without Prediabetes

Abbott Diabetes Care

NCT06921902

RECRUITING NA 664 participants

Community Engagement Alliance Against Disparities

Johns Hopkins University

NCT06607341

RECRUITING 350 participants

Inflammation, Diabetes, Ethnicity and Obesity Cohort

University of California, San Francisco

NCT03022682

RECRUITING NA 300 participants

Mechanisms of Prediabetic States in Sleep Apnea

University of Chicago

NCT04234217

RECRUITING NA 250 participants

Sisters of Heart (Hermanas de Corazón): A Community Health Worker Initiative for Improving Heart Health in Migrant Farmworker Women

Emory University

NCT07111026

RECRUITING NA 216 participants

The GRoceries Aimed at Increasing Nutrition Study

University of Pennsylvania

NCT07167004

RECRUITING NA 198 participants

Stand Up for Your Health with a Sit-stand Desk

Medical College of Wisconsin

NCT05585190

RECRUITING NA 150 participants

Efficacy of Viome's Precision Nutrition Program Towards Reducing HbA1c

Viome

NCT05465616

RECRUITING NA 150 participants

Dietary Supplementation on Body Fat Composition

Brightseed

NCT06296251

RECRUITING Phase 2 140 participants

Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health

University of California, San Diego

NCT07189234

RECRUITING NA 120 participants

Primary and Secondary Prevention of Type 2 Diabetes Mellitus in Clark County

University of Nevada, Las Vegas

NCT06387797

RECRUITING Phase 4 102 participants

Treatment to Regress to Normoglycemia in Women with a Recent History of GDM

Woman's

NCT04873050

RECRUITING 100 participants

Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)

Petter Bjornstad

NCT05008276

RECRUITING Phase 4 96 participants

The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

Philip Kern

NCT05051436

RECRUITING NA 80 participants

MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT06555952

RECRUITING NA 80 participants

Mechanisms of Fatigability With Diabetes

University of Michigan

NCT04442451

RECRUITING Early Phase 1 66 participants

Breaking up Sedentary Time to Improve Glucose Control in a Population at Risk for Developing Type 2 Diabetes

University of Colorado, Denver

NCT05041491

RECRUITING Phase 1 64 participants

Prevention of Progression of Prediabetes, Obesity and CV Risk

The University of Texas Health Science Center at San Antonio

NCT06446531

RECRUITING NA 50 participants

The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults

AdventHealth Translational Research Institute

NCT03761446

RECRUITING NA 48 participants

Full Plate Living Nutrition Education Program

University of Wisconsin, Madison

NCT07271940

RECRUITING NA 34 participants

Lifestyle Patterns and Glycemic Control

Columbia University

NCT05224986

RECRUITING NA 30 participants

Optimizing Mango's Glycemic Impact: Investigating Mango Consumption Timing in Prediabetic Individuals

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT06986161

ACTIVE NOT RECRUITING NA 31,187 participants

Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform

Signos

NCT05121844

ACTIVE NOT RECRUITING NA 1,029 participants

The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older

University of Illinois at Chicago

NCT05654142

ACTIVE NOT RECRUITING 1,000 participants

Northern Manhattan Study of Metabolism and Mind

Columbia University

NCT02470260

ACTIVE NOT RECRUITING NA 310 participants

A Shared Decision Making Intervention for Diabetes Prevention in Women With a History of Gestational Diabetes Mellitus

University of California, Los Angeles

NCT04897945

ACTIVE NOT RECRUITING NA 273 participants

Stepping Into Lifestyle Changes

University of Alabama at Birmingham

NCT05625321

ACTIVE NOT RECRUITING NA 238 participants

BRInging the Diabetes Prevention Program to GEriatric Populations

NYU Langone Health

NCT05166785

ACTIVE NOT RECRUITING NA 100 participants

Precision Diets for Diabetes Prevention

Stanford University

NCT03919877

ACTIVE NOT RECRUITING NA 66 participants

Understanding Dose Related Effects of Strawberry

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT06173765

ACTIVE NOT RECRUITING NA 30 participants

Cephalic Phase Responses to Nutritive and Non-Nutritive Sweeteners

Purdue University

NCT06387316

COMPLETED NA 974 participants

Integrated Community-Clinical Linkage Model to Promote Weight Loss Among South Asians With Pre-Diabetes

NYU Langone Health

NCT03188094

COMPLETED NA 402 participants

Effectiveness Study of Community-Based, Peer-Led Education on Weight Loss and Diabetes

Icahn School of Medicine at Mount Sinai

NCT01004848

COMPLETED NA 301 participants

Power-Up: An Effectiveness Trial of the Diabetes Prevention Program

Albert Einstein College of Medicine

NCT04104243

COMPLETED NA 288 participants

Exercise Dose-Response Effects in Prediabetes

Duke University

NCT00962962

COMPLETED 225 participants

A Study of the Function of Hormones Present In Taste Buds

National Institute on Aging (NIA)

NCT00233298

COMPLETED 207 participants

Glucose Risk Assessment in Employer Populations

DexCom

NCT04529824

COMPLETED NA 110 participants

The Effect of Real Time Continuous Glucose Monitoring in Subjects With Pre-diabetes

Walter Reed National Military Medical Center

NCT01741467

COMPLETED NA 102 participants

Healthy Body Healthy Souls in the Marshallese Population

University of Arkansas

NCT03377244

COMPLETED NA 99 participants

Balanced (Egg) Protein During Obesity Reduction: Differential Responses of Insulin Resistance by Race

Duke University

NCT03771261

COMPLETED NA 90 participants

Community-based Adolescent Diabetes Prevention Program

Icahn School of Medicine at Mount Sinai

NCT02458131

COMPLETED NA 82 participants

Dietary Exchanges With Avocado and Mango in Pre-diabetes

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT05353790

COMPLETED NA 70 participants

Effects of a Dietary Supplement Containing L-Arabinose and Trivalent Patented Food-source of Chromium on Blood Glucose and Insulin

Integrative Health Technologies

NCT01107431

COMPLETED NA 70 participants

Food as Medicine: A Quasi-Randomized Control Trial of Healthy Foods for Chronic Disease Management

Cleveland Clinic Akron General

NCT05174078

COMPLETED NA 67 participants

Fit and Trim for Diabetes Prevention

University of California, San Francisco

NCT02278939

COMPLETED NA 62 participants

Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans

University of Colorado, Denver

NCT03077360

COMPLETED NA 55 participants

Healthy Liver - Healthy Brain

University of Texas at Austin

NCT05216796

COMPLETED 45 participants

Models of Nutrition From Continuous Glucose Monitors

Texas A&M University

NCT04991142

COMPLETED NA 41 participants

Beneficial Effect of Salicylates: Insulin Action, Secretion or Clearance?

Stanford University

NCT02007577

COMPLETED NA 34 participants

Effects of Fos Biomedical Device on Diabetes Risk Factors and Sleep Quality in Adults at Risk for Type 2 Diabetes

Griffin Hospital

NCT05628597

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Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 1
Phase 3 1
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pre Diabetes Trial Landscape

60 indexed Pre Diabetes studies · 22 recruiting (37%).

Phase mix: 4 late (III/IV) vs 4 early (I/II).

Top sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology (4 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pre Diabetes?

PlainTrial tracks 60 US clinical trials for Pre Diabetes, of which 22 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pre Diabetes?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.