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Pre Diabetes clinical trials
22 of 60 indexed Pre Diabetes trials are currently recruiting.
60 US clinical trials · 22 currently recruiting
Pre Diabetes is the subject of 60 registered US clinical trials on ClinicalTrials.gov, 22 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Clinical Nutrition Research Center, Illinois Institute of Technology, running 4 of these trials.
The research picture
Pre Diabetes has 60 registered US clinical trials, 22 of them open to new participants right now, about 37% of the total.
- 22
- recruiting participants now
- 37%
- of trials open to enrollment
- 4
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology
Active & Recent Trials
60 total, page 1 of 2
Glycemic Metrics and Patterns in People With and Without Prediabetes
Abbott Diabetes Care
NCT06921902
Community Engagement Alliance Against Disparities
Johns Hopkins University
NCT06607341
Inflammation, Diabetes, Ethnicity and Obesity Cohort
University of California, San Francisco
NCT03022682
Mechanisms of Prediabetic States in Sleep Apnea
University of Chicago
NCT04234217
Sisters of Heart (Hermanas de Corazón): A Community Health Worker Initiative for Improving Heart Health in Migrant Farmworker Women
Emory University
NCT07111026
The GRoceries Aimed at Increasing Nutrition Study
University of Pennsylvania
NCT07167004
Stand Up for Your Health with a Sit-stand Desk
Medical College of Wisconsin
NCT05585190
Efficacy of Viome's Precision Nutrition Program Towards Reducing HbA1c
Viome
NCT05465616
Dietary Supplementation on Body Fat Composition
Brightseed
NCT06296251
Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health
University of California, San Diego
NCT07189234
Primary and Secondary Prevention of Type 2 Diabetes Mellitus in Clark County
University of Nevada, Las Vegas
NCT06387797
Treatment to Regress to Normoglycemia in Women with a Recent History of GDM
Woman's
NCT04873050
Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Petter Bjornstad
NCT05008276
The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics
Philip Kern
NCT05051436
MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors
Clinical Nutrition Research Center, Illinois Institute of Technology
NCT06555952
Mechanisms of Fatigability With Diabetes
University of Michigan
NCT04442451
Breaking up Sedentary Time to Improve Glucose Control in a Population at Risk for Developing Type 2 Diabetes
University of Colorado, Denver
NCT05041491
Prevention of Progression of Prediabetes, Obesity and CV Risk
The University of Texas Health Science Center at San Antonio
NCT06446531
The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults
AdventHealth Translational Research Institute
NCT03761446
Full Plate Living Nutrition Education Program
University of Wisconsin, Madison
NCT07271940
Lifestyle Patterns and Glycemic Control
Columbia University
NCT05224986
Optimizing Mango's Glycemic Impact: Investigating Mango Consumption Timing in Prediabetic Individuals
Clinical Nutrition Research Center, Illinois Institute of Technology
NCT06986161
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform
Signos
NCT05121844
The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older
University of Illinois at Chicago
NCT05654142
Northern Manhattan Study of Metabolism and Mind
Columbia University
NCT02470260
A Shared Decision Making Intervention for Diabetes Prevention in Women With a History of Gestational Diabetes Mellitus
University of California, Los Angeles
NCT04897945
Stepping Into Lifestyle Changes
University of Alabama at Birmingham
NCT05625321
BRInging the Diabetes Prevention Program to GEriatric Populations
NYU Langone Health
NCT05166785
Precision Diets for Diabetes Prevention
Stanford University
NCT03919877
Understanding Dose Related Effects of Strawberry
Clinical Nutrition Research Center, Illinois Institute of Technology
NCT06173765
Cephalic Phase Responses to Nutritive and Non-Nutritive Sweeteners
Purdue University
NCT06387316
Integrated Community-Clinical Linkage Model to Promote Weight Loss Among South Asians With Pre-Diabetes
NYU Langone Health
NCT03188094
Effectiveness Study of Community-Based, Peer-Led Education on Weight Loss and Diabetes
Icahn School of Medicine at Mount Sinai
NCT01004848
Power-Up: An Effectiveness Trial of the Diabetes Prevention Program
Albert Einstein College of Medicine
NCT04104243
Exercise Dose-Response Effects in Prediabetes
Duke University
NCT00962962
A Study of the Function of Hormones Present In Taste Buds
National Institute on Aging (NIA)
NCT00233298
Glucose Risk Assessment in Employer Populations
DexCom
NCT04529824
The Effect of Real Time Continuous Glucose Monitoring in Subjects With Pre-diabetes
Walter Reed National Military Medical Center
NCT01741467
Healthy Body Healthy Souls in the Marshallese Population
University of Arkansas
NCT03377244
Balanced (Egg) Protein During Obesity Reduction: Differential Responses of Insulin Resistance by Race
Duke University
NCT03771261
Community-based Adolescent Diabetes Prevention Program
Icahn School of Medicine at Mount Sinai
NCT02458131
Dietary Exchanges With Avocado and Mango in Pre-diabetes
Clinical Nutrition Research Center, Illinois Institute of Technology
NCT05353790
Effects of a Dietary Supplement Containing L-Arabinose and Trivalent Patented Food-source of Chromium on Blood Glucose and Insulin
Integrative Health Technologies
NCT01107431
Food as Medicine: A Quasi-Randomized Control Trial of Healthy Foods for Chronic Disease Management
Cleveland Clinic Akron General
NCT05174078
Fit and Trim for Diabetes Prevention
University of California, San Francisco
NCT02278939
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans
University of Colorado, Denver
NCT03077360
Healthy Liver - Healthy Brain
University of Texas at Austin
NCT05216796
Models of Nutrition From Continuous Glucose Monitors
Texas A&M University
NCT04991142
Beneficial Effect of Salicylates: Insulin Action, Secretion or Clearance?
Stanford University
NCT02007577
Effects of Fos Biomedical Device on Diabetes Risk Factors and Sleep Quality in Adults at Risk for Type 2 Diabetes
Griffin Hospital
NCT05628597
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 1 |
| Phase 3 | 1 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Pre Diabetes Trial Landscape
60 indexed Pre Diabetes studies · 22 recruiting (37%).
Phase mix: 4 late (III/IV) vs 4 early (I/II).
Top sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology (4 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Pre Diabetes?
PlainTrial tracks 60 US clinical trials for Pre Diabetes, of which 22 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Pre Diabetes?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.