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ClinicalTrials.gov 12 recruiting now early-phase tilt small index

Muscle-Invasive Bladder Carcinoma: early-phase trial registry

12 of 15 indexed Muscle-Invasive Bladder Carcinoma trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,140 of 28,707 conditions by registered trial count.

15 US clinical trials · 12 currently recruiting · #1,140 of 28,707 conditions by registered trial count

Muscle-Invasive Bladder Carcinoma: 15 US clinical trials tracked, 12 recruiting.

Muscle-Invasive Bladder Carcinoma is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is Shilpa Gupta, MD, running 1 of these trials.

Enrollment posture brief

Registry condition muscle-invasive-bladder-carcinoma

OPEN 12 | RECR 80% | LATE 1 | EARLY 12 | RANK #1140 | SPON 1

Nearest open-share peer: Ablation (80% recruiting · 5 trials)

Muscle-Invasive Bladder (th…80%Advanced Lung Non-Small Cell53.3%AIDS26.7%Adult Acute Myeloid Leukemia0%Adult Glioblastoma0%
Open-enrollment share among volume-matched conditions near Muscle-Invasive Bladder Carcinoma

Muscle-Invasive Bladder Carcinoma lists 12 open slots (80% of 15 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Muscle-Invasive Bladder Carcinoma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Muscle-Invasive Bladder Carcinoma is recruiting above its size-band peers.

    12 of 15 indexed trials (80%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Muscle-Invasive Bladder Carcinoma trials is spread across many organizations.

    Shilpa Gupta, MD accounts for 1 of 15 trials (6.7%). 15 distinct sponsors appear on at least one study for this condition label.

  3. Most Muscle-Invasive Bladder Carcinoma trials plan to enrol fewer than 100 people.

    Median target enrolment is 40 among the 15 trials that report a genuine target (sentinel values excluded). 12 of those (80%) plan for fewer than 100 participants.

  4. Muscle-Invasive Bladder Carcinoma research is mostly interventional.

    15 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 14Phase 28Phase 31

Open and recent trials

15 total, page 1 of 1

RECRUITING Phase 2 700 participants

Modular Trial of sEphB4-HSA in EphrinB2-High Solid Tumors

Vasgene Therapeutics

NCT06493552

RECRUITING Early Phase 1 120 participants

Prophylactic Antibiotics in Cystectomy With Diversion

University of Minnesota

NCT06190197

RECRUITING NA 70 participants

Clinical Trial to Evaluate Post-Operative Outcomes of Ureteral Stent vs Ureteral Stent Free Radical Cystectomy

Thomas Jefferson University

NCT07234968

RECRUITING Phase 1 47 participants

Enfortumab Vedotin and Pembrolizumab Combined With Radiotherapy in Muscle Invasive Bladder Cancer

University of California, San Francisco

NCT06470282

RECRUITING Phase 2 40 participants

Partial Cystectomy & Extended Pelvic Lymph Node Dissection With SOC Perioperative Systemic Therapy

Case Comprehensive Cancer Center

NCT06290687

RECRUITING Phase 2 36 participants

Gemcitabine/Cisplatin Plus Cemiplimab With or Without Fianlimab in Localized Muscle-invasive Bladder Cancer (NeoSTOP-IT)

Columbia University

NCT06571708

RECRUITING Phase 1 32 participants

Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease

Washington University School of Medicine

NCT06529822

RECRUITING NA 30 participants

Pre-Habilitation with Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)

University of Virginia

NCT05790850

RECRUITING Phase 2 24 participants

Futibatinib in Combination With Durvalumab Prior to Cystectomy for the Treatment of Muscle-Invasive Bladder Cancer Patients Who Are Ineligible for Cisplatin-based Therapy

Yuanquan Yang

NCT06263153

RECRUITING Phase 2 20 participants

Bladder Preservation for Patients With Muscle Invasive Bladder Cancer (MIBC) With Variant Histology

Leslie Ballas

NCT06417190

RECRUITING Phase 1 20 participants

Adaptive RADiation Therapy With Concurrent Sacituzumab Govitecan (SG) for Muscle Invasive Bladder Cancer

Shilpa Gupta, MD

NCT05833867

RECRUITING Phase 2 18 participants

Sacituzumab Govitecan Before Radical Cystectomy for the Treatment of Non-Urothelial Muscle Invasive Bladder Cancer

University of Washington

NCT05581589

ACTIVE NOT RECRUITING Phase 3 475 participants

Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer

National Cancer Institute (NCI)

NCT03775265

ACTIVE NOT RECRUITING Phase 2 81 participants

A Study of Risk Enabled Therapy After Neoadjuvant Immunochemotherapy for Bladder Cancer

Fox Chase Cancer Center

NCT04506554

ACTIVE NOT RECRUITING Phase 2 46 participants

Pembrolizumab in Muscle-invasive Bladder Cancer

Matthew Galsky

NCT05406713

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 8
Phase 3 1

Named interventions

Most-linked intervention names on Muscle-Invasive Bladder Carcinoma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Cisplatin Drug
3 trials
Gemcitabine Drug
2 trials
Computed Tomography Procedure
2 trials
Pembrolizumab Drug
2 trials
AMVAC + Nivolumab Drug
1 trials
SEphB4-HSA Drug
1 trials
Cystoscopy (CS) Procedure
1 trials
Transurethral Resection of Bladder Tumor Procedure
1 trials

US sites by state

Facility locations filed on Muscle-Invasive Bladder Carcinoma trials. A trial with sites in several states counts in each.

California 5 trials
Ohio 3 trials
Pennsylvania 2 trials
New York 2 trials
Washington 1 trials
Virginia 1 trials
Texas 1 trials
New Mexico 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Muscle-Invasive Bladder Carcinoma page

15 registered trials, 12 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

  • 12 Muscle-Invasive Bladder Carcinoma trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
  • Shilpa Gupta, MD sponsors the most Muscle-Invasive Bladder Carcinoma trials on record, review their full trial history before evaluating a specific study. See Shilpa Gupta, MD's trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Muscle-Invasive Bladder Carcinoma condition card totals 15 registered trials; most-linked intervention Cisplatin; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.