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ClinicalTrials.gov 7 recruiting now official registry

Metastatic Colorectal Adenocarcinoma clinical trials

7 of 15 indexed Metastatic Colorectal Adenocarcinoma trials are currently recruiting.

15 US clinical trials · 7 currently recruiting

Metastatic Colorectal Adenocarcinoma is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 3 of these trials.

The research picture

Metastatic Colorectal Adenocarcinoma has 15 registered US clinical trials, 7 of them open to new participants right now, about 47% of the total.

7
recruiting participants now
47%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
3
top sponsor: M.D. Anderson Cancer Center
Phase 18Phase 25Phase 32

Active & Recent Trials

15 total, page 1 of 1

RECRUITING Phase 3 364 participants

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study

Alliance for Clinical Trials in Oncology

NCT05673148

RECRUITING Phase 1 260 participants

A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors

Pfizer

NCT07318805

RECRUITING Phase 2 102 participants

Amplitude-Modulated Radiofrequency Electromagnetic Fields (AM RF EMF) in Combination With Fruquintinib in Refractory Metastatic Colorectal Cancer

Barbara Ann Karmanos Cancer Institute

NCT07130903

RECRUITING Phase 1 45 participants

Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer

Roswell Park Cancer Institute

NCT04511039

RECRUITING Phase 1 30 participants

Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer

National Cancer Institute (NCI)

NCT06102902

RECRUITING Phase 1 24 participants

Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer

National Cancer Institute (NCI)

NCT06696768

RECRUITING Phase 1 15 participants

Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer

University of Southern California

NCT06336902

ACTIVE NOT RECRUITING Phase 3 120 participants

Testing the Addition of Atezolizumab to Combination Chemotherapy or Atezolizumab Alone for Metastatic Colon or Rectal Cancer, the COMMIT Study

National Cancer Institute (NCI)

NCT02997228

ACTIVE NOT RECRUITING Phase 1 117 participants

Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer

M.D. Anderson Cancer Center

NCT02600949

ACTIVE NOT RECRUITING Phase 2 59 participants

Panitumumab With or Without Trametinib in Treating Patients With Stage IV Colorectal Cancer

M.D. Anderson Cancer Center

NCT03087071

ACTIVE NOT RECRUITING Phase 1 28 participants

Botensilimab, Balstilimab and Regorafenib for the Treatment of Patients With Microsatellite Stable Metastatic Colorectal Cancer Who Have Progressed on Prior Chemotherapy

City of Hope Medical Center

NCT05672316

ACTIVE NOT RECRUITING Phase 2 22 participants

Regorafenib, With Cetuximab or Panitumumab, for the Treatment of Unresectable, Locally Advanced, or Metastatic Colorectal Cancer

Academic and Community Cancer Research United

NCT04117945

ACTIVE NOT RECRUITING Phase 1 20 participants

FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer

City of Hope Medical Center

NCT05627635

ACTIVE NOT RECRUITING Phase 2 15 participants

Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders

M.D. Anderson Cancer Center

NCT04729322

COMPLETED Phase 2 11 participants

Regorafenib in Good Performance Status Patients With Newly Diagnosed Metastatic Colorectal Adenocarcinoma

Memorial Sloan Kettering Cancer Center

NCT02023333

Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 5
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Colorectal Adenocarcinoma Trial Landscape

15 indexed Metastatic Colorectal Adenocarcinoma studies · 7 recruiting (47%).

Phase mix: 2 late (III/IV) vs 13 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (3 trials), 9 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Colorectal Adenocarcinoma?

PlainTrial tracks 15 US clinical trials for Metastatic Colorectal Adenocarcinoma, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Colorectal Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.