Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
ME/CFS: early-phase trial registry
4 of 4 indexed ME/CFS trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #4,115 of 28,707 conditions by registered trial count.
4 US clinical trials · 4 currently recruiting · #4,115 of 28,707 conditions by registered trial count
ME/CFS: 4 US clinical trials tracked, 4 recruiting.
ME/CFS is the subject of 4 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Brain Inflammation Collaborative, running 1 of these trials.
Enrollment posture brief
Registry condition mecfs
OPEN 4 | RECR 100% | LATE 0 | EARLY 2 | RANK #4115 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Aortic Arch Aneurysm (100% recruiting · 5 trials)
ME/CFS lists 4 open slots (100% of 4 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for ME/CFS on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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ME/CFS is recruiting above its size-band peers.
4 of 4 indexed trials (100%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
Open and recent trials
4 total, page 1 of 1
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
Brain Inflammation Collaborative
NCT04806620
Patient-Centered Assessment of Symptoms and Outcomes
National Center for Complementary and Integrative Health (NCCIH)
NCT03952624
LIFT: Life Improvement Trial
Brigham and Women's Hospital
NCT06366724
The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Nova Southeastern University
NCT06211062
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on ME/CFS records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on ME/CFS trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this ME/CFS page
4 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 ME/CFS trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Brain Inflammation Collaborative sponsors the most ME/CFS trials on record, review their full trial history before evaluating a specific study. See Brain Inflammation Collaborative's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This ME/CFS condition card totals 4 registered trials; most-linked intervention Placebo; top US site state Wisconsin. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.