Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Locked-in Syndrome clinical trials
4 of 5 indexed Locked-in Syndrome trials are currently recruiting.
Corpus placement: #3,391 of 28,707 conditions by registered trial count.
5 US clinical trials · 4 currently recruiting · #3,391 of 28,707 conditions by registered trial count
Locked-in Syndrome: 5 US clinical trials tracked, 4 recruiting.
Locked-in Syndrome is the subject of 5 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. The most active sponsor is Leigh R. Hochberg, MD, PhD., running 3 of these trials.
Enrollment posture brief
Registry condition locked-in-syndrome
OPEN 4 | RECR 80% | LATE 0 | EARLY 0 | RANK #3391 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Acute Leukemia of Ambiguous Lineage (80% recruiting · 10 trials)
Locked-in Syndrome lists 4 open slots (80% of 5 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Locked-in Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Locked-in Syndrome is recruiting above its size-band peers.
4 of 5 indexed trials (80%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Locked-in Syndrome research.
Leigh R. Hochberg, MD, PhD. accounts for 3 of 5 trials (60%). 3 distinct sponsors appear on at least one study for this condition label.
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Most Locked-in Syndrome trials plan to enrol fewer than 100 people.
Median target enrolment is 3 among the 5 trials that report a genuine target (sentinel values excluded). 5 of those (100%) plan for fewer than 100 participants.
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Locked-in Syndrome research is mostly interventional.
5 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
5 total, page 1 of 1
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Leigh R. Hochberg, MD, PhD.
NCT00912041
Investigation on the Cortical Communication (CortiCom) System
Johns Hopkins University
NCT03567213
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
Leigh R. Hochberg, MD, PhD.
NCT05724173
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)
Leigh R. Hochberg, MD, PhD.
NCT06094205
Feasibility of mindBEAGLE in Disorders of Consciousness or Locked-In Syndrome
Massachusetts General Hospital
NCT02772302
Phase Distribution
Phase data not available
Top Sponsors
Named interventions
Most-linked intervention names on Locked-in Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Locked-in Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Locked-in Syndrome page
5 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 Locked-in Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Leigh R. Hochberg, MD, PhD. sponsors the most Locked-in Syndrome trials on record, review their full trial history before evaluating a specific study. See Leigh R. Hochberg, MD, PhD.'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Locked-in Syndrome condition card totals 5 registered trials; most-linked intervention BrainGate Neural Interface System; top US site state Massachusetts. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.