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ClinicalTrials.gov official registry

Locally Advanced Malignant Neoplasm clinical trials

All 12 indexed Locally Advanced Malignant Neoplasm trials have closed enrollment.

12 US clinical trials ·

Locally Advanced Malignant Neoplasm is the subject of 12 registered US clinical trials on ClinicalTrials.gov, none currently recruiting. 1 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 7 of these trials.

The research picture

Locally Advanced Malignant Neoplasm has 12 registered US clinical trials; none are currently listed as recruiting, so most are completed or in follow-up.

0
recruiting participants now
0%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
7
top sponsor: M.D. Anderson Cancer Center
Phase 13Phase 23Phase 31

Active & Recent Trials

12 total, page 1 of 1

ACTIVE NOT RECRUITING NA 406 participants

Preference of Room Setting and Waiting Time in Patients With Advanced, Locally Advanced, or Metastatic Cancer and Their Caregivers Who Are Seen in the Outpatient Supportive/Palliative Care Center

M.D. Anderson Cancer Center

NCT03671226

ACTIVE NOT RECRUITING 141 participants

Financial Distress in Advanced Cancer Patients

M.D. Anderson Cancer Center

NCT04053517

ACTIVE NOT RECRUITING Phase 2 110 participants

Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care

M.D. Anderson Cancer Center

NCT03743649

ACTIVE NOT RECRUITING Phase 2 70 participants

Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer

M.D. Anderson Cancer Center

NCT03021486

ACTIVE NOT RECRUITING NA 40 participants

Microbiome and Rectal Cancer

University of South Florida

NCT04223102

COMPLETED 351 participants

Caregiver Burden, Quality of Life, and Symptom Distress at Different Palliative Cancer Care Settings

M.D. Anderson Cancer Center

NCT04186884

COMPLETED NA 125 participants

Videos and Questionnaires in Assessing Patient Perception of Physician's Compassion, Communication Skills, and Professionalism During Clinic Visits

M.D. Anderson Cancer Center

NCT03856060

COMPLETED Phase 1 45 participants

A Phase 1 Study to Investigate Axatilimab Alone or in Combination With Durvalumab in Patients With Solid Tumors

Syndax Pharmaceuticals

NCT03238027

COMPLETED Phase 1 30 participants

A Study of ALT-836 in Combination With Gemcitabine for Locally Advanced or Metastatic Solid Tumors

Altor BioScience

NCT01325558

COMPLETED Phase 3 28 participants

Extraperitoneal Para-aortic Lymph Node Dissection (EPLND) for Cervix

M.D. Anderson Cancer Center

NCT01365156

COMPLETED Phase 1 10 participants

Chemoimmunotherapy and Radiation in Pancreatic Cancer

Providence Health & Services

NCT01903083

COMPLETED Phase 2 10 participants

Study of Propranolol in Newly Diagnosed Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

Columbia University

NCT01847001

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 3
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Locally Advanced Malignant Neoplasm Trial Landscape

12 indexed Locally Advanced Malignant Neoplasm studies · 0 recruiting (0%).

Phase mix: 1 late (III/IV) vs 6 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (7 trials), 5 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Locally Advanced Malignant Neoplasm?

PlainTrial tracks 12 US clinical trials for Locally Advanced Malignant Neoplasm, of which 0 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Locally Advanced Malignant Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.