Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Leptomeningeal Metastasis: early-phase trial registry
5 of 7 indexed Leptomeningeal Metastasis trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #2,497 of 28,707 conditions by registered trial count.
7 US clinical trials · 5 currently recruiting · #2,497 of 28,707 conditions by registered trial count
Leptomeningeal Metastasis: 7 US clinical trials tracked, 5 recruiting.
Leptomeningeal Metastasis is the subject of 7 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Plus Therapeutics, running 2 of these trials.
Enrollment posture brief
Registry condition leptomeningeal-metastasis
OPEN 5 | RECR 71% | LATE 0 | EARLY 6 | RANK #2497 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Advanced Endometrial Carcinoma (71% recruiting · 7 trials)
Leptomeningeal Metastasis lists 5 open slots (71% of 7 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Leptomeningeal Metastasis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Leptomeningeal Metastasis is recruiting above its size-band peers.
5 of 7 indexed trials (71.4%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Leptomeningeal Metastasis research.
Plus Therapeutics accounts for 2 of 7 trials (28.6%). 5 distinct sponsors appear on at least one study for this condition label.
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Most Leptomeningeal Metastasis trials plan to enrol fewer than 100 people.
Median target enrolment is 30 among the 7 trials that report a genuine target (sentinel values excluded). 6 of those (85.7%) plan for fewer than 100 participants.
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Leptomeningeal Metastasis research is mostly interventional.
6 interventional and 1 observational studies make up this index (85.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
7 total, page 1 of 1
Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis
University of Zurich
NCT06417710
Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease
H. Lee Moffitt Cancer Center and Research Institute
NCT04588545
Concurrent Azeliragon With Craniospinal Irradiation
NYU Langone Health
NCT06724926
Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer
Memorial Sloan Kettering Cancer Center
NCT06058988
Multiple Dose Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases
Plus Therapeutics
NCT07098806
GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases
Memorial Sloan Kettering Cancer Center
NCT04192981
Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases
Plus Therapeutics
NCT05034497
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Leptomeningeal Metastasis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Leptomeningeal Metastasis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Leptomeningeal Metastasis page
7 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 5 Leptomeningeal Metastasis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Plus Therapeutics sponsors the most Leptomeningeal Metastasis trials on record, review their full trial history before evaluating a specific study. See Plus Therapeutics's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Leptomeningeal Metastasis condition card totals 7 registered trials; most-linked intervention 186RNL; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.