Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Klinefelter Syndrome: later-stage trial registry
1 of 5 indexed Klinefelter Syndrome trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #3,391 of 28,707 conditions by registered trial count.
5 US clinical trials · 1 currently recruiting · #3,391 of 28,707 conditions by registered trial count
Klinefelter Syndrome: 5 US clinical trials tracked, 1 recruiting.
Klinefelter Syndrome is the subject of 5 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 0 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 4 of these trials.
Enrollment posture brief
Registry condition klinefelter-syndrome
OPEN 1 | RECR 20% | LATE 2 | EARLY 0 | RANK #3391 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive (20% recruiting · 10 trials)
Klinefelter Syndrome lists 1 open slots (20% of 5 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Klinefelter Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Klinefelter Syndrome is recruiting below its size-band peers.
1 of 5 indexed trials (20%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Klinefelter Syndrome research.
University of Colorado, Denver accounts for 4 of 5 trials (80%). 2 distinct sponsors appear on at least one study for this condition label.
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Most Klinefelter Syndrome trials plan to enrol fewer than 100 people.
Median target enrolment is 44 among the 5 trials that report a genuine target (sentinel values excluded). 3 of those (60%) plan for fewer than 100 participants.
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Klinefelter Syndrome research leans observational.
2 interventional and 3 observational studies make up this index (40% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
5 total, page 1 of 1
The eXtroardinarY Babies Study: Natural History of Health and Neurodevelopment in Infants and Young Children With Sex Chromosome Trisomy
University of Colorado, Denver
NCT03396562
Interrogating Fatty Acid Metabolism Impairment and Clinical Correlates in Males with Klinefelter Syndrome
University of Colorado, Denver
NCT05498090
Expanded Noninvasive Genomic Medical Assessment: The Enigma Study
Progenity
NCT02787486
Cardiometabolic Profiles of Boys With Klinefelter Syndrome
University of Colorado, Denver
NCT02723305
Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment
University of Colorado, Denver
NCT02408445
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Klinefelter Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Klinefelter Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Klinefelter Syndrome page
5 registered trials, 1 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 1 Klinefelter Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Colorado, Denver sponsors the most Klinefelter Syndrome trials on record, review their full trial history before evaluating a specific study. See University of Colorado, Denver's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Klinefelter Syndrome condition card totals 5 registered trials; most-linked intervention Blood sampling for Laboratory Developed Test (LDT) analysis; top US site state Colorado. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.