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ClinicalTrials.gov 8 recruiting now early-phase tilt small index

Electronic Cigarette Use: early-phase trial registry

8 of 16 indexed Electronic Cigarette Use trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,060 of 28,707 conditions by registered trial count.

16 US clinical trials · 8 currently recruiting · #1,060 of 28,707 conditions by registered trial count

Electronic Cigarette Use: 16 US clinical trials tracked, 8 recruiting.

Electronic Cigarette Use is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Florida International University, running 2 of these trials.

Enrollment posture brief

Registry condition electronic-cigarette-use

OPEN 8 | RECR 50% | LATE 2 | EARLY 4 | RANK #1060 | SPON 2

Nearest open-share peer: Abdominal Aortic Aneurysms (50% recruiting · 6 trials)

Adolescent62.5%Alcohol Intoxication56.3%Electronic Cigarette Use (th…50%AL Amyloidosis43.8%Allergy18.8%
Open-enrollment share among volume-matched conditions near Electronic Cigarette Use

Electronic Cigarette Use lists 8 open slots (50% of 16 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Electronic Cigarette Use on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Electronic Cigarette Use is recruiting above its size-band peers.

    8 of 16 indexed trials (50%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Electronic Cigarette Use trials is spread across many organizations.

    Florida International University accounts for 2 of 16 trials (12.5%). 12 distinct sponsors appear on at least one study for this condition label.

  3. Typical Electronic Cigarette Use enrolment sits around 100 participants.

    Median target enrolment is 100 among the 16 trials that report a genuine target (sentinel values excluded). 8 of those (50%) plan for fewer than 100 participants.

  4. Electronic Cigarette Use research is mostly interventional.

    15 interventional and 1 observational studies make up this index (93.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 13Phase 21Phase 42

Open and recent trials

16 total, page 1 of 1

RECRUITING 600 participants

Effects of E-cigarette Use on Health

University of Wisconsin, Madison

NCT06610838

RECRUITING Phase 4 500 participants

The Avenues Study: Dual Use Cessation

University of Wisconsin, Madison

NCT06474299

RECRUITING NA 250 participants

Effect of Menthol on ENDS Users' Addiction and Exposure

Florida International University

NCT05338801

RECRUITING NA 200 participants

Effects of Social Media Use on Young Adults' E-Cigarette Use

University of Oklahoma

NCT06142877

RECRUITING Phase 1 100 participants

Effect of Cannabis on E-Cigarette Use Behavior

Johns Hopkins University

NCT06609109

RECRUITING NA 80 participants

Developing and Testing Health Warning Labels on the ENDS Device

Florida International University

NCT04907136

RECRUITING NA 40 participants

Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC

Massachusetts General Hospital

NCT05881304

RECRUITING Early Phase 1 24 participants

Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use

University of Iowa

NCT06489249

ACTIVE NOT RECRUITING NA 432 participants

Development of UP2UTobacco for High School Youth

University of Virginia

NCT05396911

ACTIVE NOT RECRUITING Phase 4 240 participants

Methadone-Maintained Smokers Switching to E-Cigarettes

Butler Hospital

NCT05206435

COMPLETED NA 569 participants

PACE Vape Messaging Study

University of Vermont

NCT04450537

COMPLETED Phase 2 77 participants

E-cigarette Nicotine Study

University of Vermont

NCT04709471

COMPLETED NA 33 participants

Assessing Electronic Cigarette Nicotine Flux

Virginia Commonwealth University

NCT04378907

COMPLETED NA 17 participants

E-cigarettes for Harm Reduction in Adults With Asthma

Brown University

NCT05278065

COMPLETED Early Phase 1 16 participants

Vaporized Nicotine and Autonomic Control

Michigan Technological University

NCT04613609

COMPLETED NA 12 participants

The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment

Virginia Commonwealth University

NCT04522973

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 1
Phase 4 2

Named interventions

Most-linked intervention names on Electronic Cigarette Use records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Beverage without ethanol and E-cigarette liquid without ethanol Other
1 trials
Beverage without ethanol and E-cigarette liquid with ethanol Other
1 trials
Beverage with ethanol and E-cigarette liquid without ethanol Other
1 trials
Beverage with ethanol and E-cigarette liquid with ethanol Other
1 trials
Electronic Cigarette without nicotine Device
1 trials
Electronic Cigarette containing nicotine Device
1 trials
Nicotine Other
1 trials
Cigarette Smokers/ECIG users: 30 mg/ml nicotine concentration Other
1 trials

US sites by state

Facility locations filed on Electronic Cigarette Use trials. A trial with sites in several states counts in each.

Virginia 3 trials
Wisconsin 2 trials
Vermont 2 trials
Rhode Island 2 trials
Florida 2 trials
Oklahoma 1 trials
Michigan 1 trials
Maryland 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Electronic Cigarette Use page

16 registered trials, 8 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Electronic Cigarette Use condition card totals 16 registered trials; most-linked intervention Beverage without ethanol and E-cigarette liquid without ethanol; top US site state Virginia. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.