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Electronic Cigarette Use clinical trials
Every US clinical trial registered for Electronic Cigarette Use — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
16 US clinical trials · 8 currently recruiting
The research picture
Electronic Cigarette Use has 16 registered US clinical trials, 8 of them open to new participants right now — about 50% of the total.
- 8
- recruiting participants now
- 50%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Florida International University
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Effects of E-cigarette Use on Health
University of Wisconsin, Madison
NCT06610838
The Avenues Study: Dual Use Cessation
University of Wisconsin, Madison
NCT06474299
Effect of Menthol on ENDS Users' Addiction and Exposure
Florida International University
NCT05338801
Effects of Social Media Use on Young Adults' E-Cigarette Use
University of Oklahoma
NCT06142877
Effect of Cannabis on E-Cigarette Use Behavior
Johns Hopkins University
NCT06609109
Developing and Testing Health Warning Labels on the ENDS Device
Florida International University
NCT04907136
Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC
Massachusetts General Hospital
NCT05881304
Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use
University of Iowa
NCT06489249
Development of UP2UTobacco for High School Youth
University of Virginia
NCT05396911
Methadone-Maintained Smokers Switching to E-Cigarettes
Butler Hospital
NCT05206435
PACE Vape Messaging Study
University of Vermont
NCT04450537
E-cigarette Nicotine Study
University of Vermont
NCT04709471
Assessing Electronic Cigarette Nicotine Flux
Virginia Commonwealth University
NCT04378907
E-cigarettes for Harm Reduction in Adults With Asthma
Brown University
NCT05278065
Vaporized Nicotine and Autonomic Control
Michigan Technological University
NCT04613609
The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment
Virginia Commonwealth University
NCT04522973
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 1 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Electronic Cigarette Use Trial Landscape
ClinicalTrials.gov lists 16 US studies indexed under Electronic Cigarette Use, and 8 of those are currently open to recruitment — roughly 50% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Electronic Cigarette Use shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Electronic Cigarette Use is led by Florida International University with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 16 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Electronic Cigarette Use?
PlainTrial tracks 16 US clinical trials for Electronic Cigarette Use, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Electronic Cigarette Use?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.