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ClinicalTrials.gov 8 recruiting now official registry

Electronic Cigarette Use clinical trials

Every US clinical trial registered for Electronic Cigarette Use — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

16 US clinical trials · 8 currently recruiting

The research picture

Electronic Cigarette Use has 16 registered US clinical trials, 8 of them open to new participants right now — about 50% of the total.

8
recruiting participants now
50%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: Florida International University

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 600 participants

Effects of E-cigarette Use on Health

University of Wisconsin, Madison

NCT06610838

RECRUITING Phase 4 500 participants

The Avenues Study: Dual Use Cessation

University of Wisconsin, Madison

NCT06474299

RECRUITING NA 250 participants

Effect of Menthol on ENDS Users' Addiction and Exposure

Florida International University

NCT05338801

RECRUITING NA 200 participants

Effects of Social Media Use on Young Adults' E-Cigarette Use

University of Oklahoma

NCT06142877

RECRUITING Phase 1 100 participants

Effect of Cannabis on E-Cigarette Use Behavior

Johns Hopkins University

NCT06609109

RECRUITING NA 80 participants

Developing and Testing Health Warning Labels on the ENDS Device

Florida International University

NCT04907136

RECRUITING NA 40 participants

Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC

Massachusetts General Hospital

NCT05881304

RECRUITING Early Phase 1 24 participants

Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use

University of Iowa

NCT06489249

ACTIVE NOT RECRUITING NA 432 participants

Development of UP2UTobacco for High School Youth

University of Virginia

NCT05396911

ACTIVE NOT RECRUITING Phase 4 240 participants

Methadone-Maintained Smokers Switching to E-Cigarettes

Butler Hospital

NCT05206435

COMPLETED NA 569 participants

PACE Vape Messaging Study

University of Vermont

NCT04450537

COMPLETED Phase 2 77 participants

E-cigarette Nicotine Study

University of Vermont

NCT04709471

COMPLETED NA 33 participants

Assessing Electronic Cigarette Nicotine Flux

Virginia Commonwealth University

NCT04378907

COMPLETED NA 17 participants

E-cigarettes for Harm Reduction in Adults With Asthma

Brown University

NCT05278065

COMPLETED Early Phase 1 16 participants

Vaporized Nicotine and Autonomic Control

Michigan Technological University

NCT04613609

COMPLETED NA 12 participants

The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment

Virginia Commonwealth University

NCT04522973

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 1
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Electronic Cigarette Use Trial Landscape

ClinicalTrials.gov lists 16 US studies indexed under Electronic Cigarette Use, and 8 of those are currently open to recruitment — roughly 50% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Electronic Cigarette Use shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Electronic Cigarette Use is led by Florida International University with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 16 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Electronic Cigarette Use?

PlainTrial tracks 16 US clinical trials for Electronic Cigarette Use, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Electronic Cigarette Use?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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