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NCT00100412 · ClinicalTrials.gov registry record · NA
Hyporeactivity and Gulf War Illness
A NA study of Post Traumatic Stress Disorder and Chronic Fatigue Syndrome, sponsored by US Department of Veterans Affairs.
- Completed
- Registry status
- NA
- Development phase
- 1
- Study location
NCT00100412: Completed NA study of Post Traumatic Stress Disorder and Chronic Fatigue Syndrome, sponsored by US Department of Veterans Affairs.
NCT00100412 is a NA study of Post Traumatic Stress Disorder and Chronic Fatigue Syndrome that has completed, run by US Department of Veterans Affairs. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00100412, a NA study of Post Traumatic Stress Disorder and Chronic Fatigue Syndrome, has completed, sponsored by US Department of Veterans Affairs.
- COMPLETED
- Registry status
- NA
- Development phase
- 1
- Study location
Study Summary
This research project is a follow-up to the prior VA-funded study that found that chronic fatigue reported by many Gulf War veterans may be a symptom of dysfunctional cardiovascular stress response regulation. Specifically, ill veterans had diminished autonomic responses during demanding psychosocial tasks involving high level cognitive processing and emotional stress. There was a close relationship between clinical status of ill veterans and their inability to mount an appropriate physiological response under stress. The main objective of the present investigation is to determine the specific mechanism through which this abnormality may contribute to Gulf War-related chronic fatigue. We also observed that Gulf veterans with posttraumatic stress disorder (PTSD) had the most dampened autonomic activation to stressors involving higher brain activities. The second major focus of this study is to explore the role of a psychiatric disorder, specifically PTSD, as a factor in abnormalities in stress response regulation. This aspect of the study may also provide pertinent information as to the role of stress of military deployment as a contributing factor in post-Gulf War illnesses.
Conditions Studied
Interventions
- DRUG Graded dobutamine infusions
- DRUG Graded phenylephrine injections
- BEHAVIORAL Psychosocial challenge involving socioevaluative public speaking
Study Locations (1)
New Jersey
- Gulf War Research Center - East Orange
Trial Details
| Field | Value |
|---|---|
| Start Date | 1999-10 |
| Est. Completion | 2002-09 |
| Phase | NA |
What the finished NCT00100412 record still lists
NCT00100412 is an interventional study that assigns participants to a tested intervention. An enrollment target was not published in the registry record, which is common for early-stage or observational entries.
The record links to 3 conditions, with Post Traumatic Stress Disorder appearing as the primary indexed condition, and to 3 interventions - of which Graded dobutamine infusions is the first listed.
NCT00100412 reports a single indexed study location in New Jersey.
Frequently Asked Questions
What is clinical trial NCT00100412 about?
NCT00100412 is a clinical study titled "Hyporeactivity and Gulf War Illness". This research project is a follow-up to the prior VA-funded study that found that chronic fatigue reported by many Gulf War veterans may be a symptom of dysfunctional cardiovascular stress response regulation. Specifically, ill veterans had diminished autonomic responses during demanding psychosocia...
What is the current status of trial NCT00100412?
This trial is currently completed. It is a NA study. The study started on 1999-10. Estimated completion is 2002-09.
What conditions does trial NCT00100412 study?
This clinical trial studies the following conditions: Post Traumatic Stress Disorder, Chronic Fatigue Syndrome, Gulf War Syndrome.
What interventions are being tested in trial NCT00100412?
The interventions under investigation include: Graded dobutamine infusions (DRUG), Graded phenylephrine injections (DRUG), Psychosocial challenge involving socioevaluative public speaking (BEHAVIORAL).
Who is sponsoring clinical trial NCT00100412?
This trial is sponsored by US Department of Veterans Affairs, which has 632 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00100412 being conducted?
This trial has 1 study location across New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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