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NCT02286154 · ClinicalTrials.gov registry record · NA
Therapeutic Response Evaluation and Adherence Trial (TREAT)
A NA study of Anemia, Sickle Cell, sponsored by Children's Hospital Medical Center, Cincinnati.
- Active
- Registry status
- NA
- Development phase
- 150
- Enrollment target
- 1
- Study location
NCT02286154: Active NA study of Anemia, Sickle Cell, sponsored by Children's Hospital Medical Center, Cincinnati.
NCT02286154 is a NA study of Anemia, Sickle Cell that is active but no longer recruiting, run by Children's Hospital Medical Center, Cincinnati. The registered enrollment target is 150 participants, above the 109-participant average among 17 other Anemia, Sickle Cell trials with a reported enrollment target (38% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02286154, a NA study of Anemia, Sickle Cell, is active but no longer recruiting, sponsored by Children's Hospital Medical Center, Cincinnati.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
The primary objectives of this prospective study of hydroxyurea for children with sickle cell anemia are 1) Develop and prospectively evaluate a population pharmacokinetic/pharmacodynamics model to predict the maximum tolerated dose (MTD); 2) Identify urine biomarkers of hydroxyurea adherence using a novel metabolomics approach; 3) Identify pharmacogenomics modifiers of hydroxyurea MTD; and 4) Longitudinal monitoring of the effect of hydroxyurea upon organ function and quality of life.
Primary Outcome
Time it takes to reach maximum tolerated dose (MTD) of hydroxyurea quantified in months.
Conditions Studied
Interventions
- DRUG Hydroxyurea
Study Locations (1)
Ohio
- Cincinnati Children's Hospital Medical Center - Cincinnati
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2014-10 |
| Est. Completion | 2026-12 |
| Phase | NA |
What the registry record for NCT02286154 still lists
NCT02286154 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, above the 109-participant average among 17 other Anemia, Sickle Cell trials with a reported enrollment target (38% higher).
The record links to 1 condition, with Anemia, Sickle Cell appearing as the primary indexed condition, and to 1 intervention - of which Hydroxyurea is the first listed.
NCT02286154 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT02286154 about?
NCT02286154 is a clinical study titled "Therapeutic Response Evaluation and Adherence Trial (TREAT)". The primary objectives of this prospective study of hydroxyurea for children with sickle cell anemia are 1) Develop and prospectively evaluate a population pharmacokinetic/pharmacodynamics model to predict the maximum tolerated dose (MTD); 2) Identify urine biomarkers of hydroxyurea adherence using ...
What is the current status of trial NCT02286154?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 150 participants. The study started on 2014-10. Estimated completion is 2026-12.
What conditions does trial NCT02286154 study?
This clinical trial studies the following conditions: Anemia, Sickle Cell.
What interventions are being tested in trial NCT02286154?
The interventions under investigation include: Hydroxyurea (DRUG).
Who is sponsoring clinical trial NCT02286154?
This trial is sponsored by Children's Hospital Medical Center, Cincinnati, which has 571 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02286154 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Anemia, Sickle Cell
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02286154's enrollment target sits among peer trials
150 5th of 17 higher than 12 of 17 other Anemia, Sickle Cell trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Anemia, Sickle Cell trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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