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NCT07477457 · ClinicalTrials.gov registry record · Phase 2
A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma
A Phase 2 study of Osteosarcoma and Metastasis, sponsored by Memorial Sloan Kettering Cancer Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 45
- Enrollment target
- 7
- Study locations
NCT07477457: Recruiting Phase 2 study of Osteosarcoma and Metastasis, sponsored by Memorial Sloan Kettering Cancer Center.
NCT07477457 is a Phase 2 study of Osteosarcoma and Metastasis that is actively recruiting participants, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 45 participants, below the 301-participant average among 46 other Osteosarcoma trials with a reported enrollment target (85% lower). The trial reports 7 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07477457, a Phase 2 study of Osteosarcoma and Metastasis, is actively recruiting participants, sponsored by Memorial Sloan Kettering Cancer Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 45 participants
- Enrollment target
- 7
- Study locations
Study Summary
The researchers are doing this study to find out whether adding gefitinib, trametinib, disulfiram, and sunitinib to standard chemotherapy is a more effective treatment approach for people with osteosarcoma than standard chemotherapy on its own. The researchers will also look at the safety of adding these drugs to standard chemotherapy. The researchers will also use the additional research biopsies from Cohort 1 participants to learn more about how osteosarcoma survives during chemotherapy.
Primary Outcome
Response will be determined by the investigator and progression will be guided by RECIST 1.1 criteria
Conditions Studied
Interventions
- DRUG Cisplatin
- DRUG Doxorubicin
- DRUG Trametinib
- DRUG Methotrexate
- DRUG Gefitinib
Study Locations (7)
New York
- Memorial Sloan Kettering at Suffolk-Commack (Limited Protocol Activities) - Commack
- Memorial Sloan Kettering at Westchester (Limited Protocol Activities) - Harrison
- Memorial Sloan Kettering Cancer Center (All Protocol Activites) - New York
- Memorial Sloan Kettering at Nassau (Limited Protocol Activities) - Uniondale
New Jersey
- Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities) - Basking Ridge
- Memorial Sloan Kettering at Monmouth (Limited Protocol Activities) - Middletown
- Memorial Sloan Kettering at Bergen (Limited Protocol Activities) - Montvale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2026-03-11 |
| Est. Completion | 2028-03-11 |
| Phase | Phase 2 |
What NCT07477457 shows while recruiting
NCT07477457 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 45 participants, a relatively small participant target, below the 301-participant average among 46 other Osteosarcoma trials with a reported enrollment target (85% lower).
The record links to 2 conditions, with Osteosarcoma appearing as the primary indexed condition, and to 5 interventions - of which Cisplatin is the first listed.
NCT07477457 lists 7 locations in 2 states (New York, New Jersey).
Frequently Asked Questions
What is clinical trial NCT07477457 about?
NCT07477457 is a clinical study titled "A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma". The researchers are doing this study to find out whether adding gefitinib, trametinib, disulfiram, and sunitinib to standard chemotherapy is a more effective treatment approach for people with osteosarcoma than standard chemotherapy on its own. The researchers will also look at the safety of adding ...
What is the current status of trial NCT07477457?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 45 participants. The study started on 2026-03-11. Estimated completion is 2028-03-11.
What conditions does trial NCT07477457 study?
This clinical trial studies the following conditions: Osteosarcoma, Metastasis.
What interventions are being tested in trial NCT07477457?
The interventions under investigation include: Cisplatin (DRUG), Doxorubicin (DRUG), Trametinib (DRUG), Methotrexate (DRUG), Gefitinib (DRUG).
Who is sponsoring clinical trial NCT07477457?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07477457 being conducted?
This trial has 7 study locations across New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Osteosarcoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07477457's enrollment target sits among peer trials
45 22nd of 46 higher than 25 of 46 other Osteosarcoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Osteosarcoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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