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NCT07465224 · ClinicalTrials.gov registry record · Phase 2

A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus

A Phase 2 study of Type 2 Diabetes Mellitus (T2DM), sponsored by Alnylam Pharmaceuticals.

Recruiting
Registry status
Phase 2
Development phase
40
Enrollment target
1
Study location

NCT07465224 is a Phase 2 study of Type 2 Diabetes Mellitus (T2DM) that is actively recruiting participants, run by Alnylam Pharmaceuticals. The registered enrollment target is 40 participants, below the 520-participant average among 24 other Type 2 Diabetes Mellitus (T2DM) trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT07465224, a Phase 2 study of Type 2 Diabetes Mellitus (T2DM), is actively recruiting participants, sponsored by Alnylam Pharmaceuticals.

RECRUITING
Registry status
Phase 2
Development phase
40 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is to evaluate the effect of a single dose of ALN-4324 on whole-body insulin sensitivity in participants with T2DM

Conditions Studied

Type 2 Diabetes Mellitus (T2DM)

Interventions

  • DRUG Placebo
  • DRUG ALN-4324

Study Locations (1)

California

  • Clinical Trial Site - Chula Vista

Trial Details

FieldValue
Enrollment Target 40 participants
Start Date 2026-01-15
Est. Completion 2027-05-28
Phase Phase 2

Sponsor

Alnylam Pharmaceuticals

49 total trials

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What the Registry Record Tells You About NCT07465224

The ClinicalTrials.gov registry entry for NCT07465224 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 520-participant average among 24 other Type 2 Diabetes Mellitus (T2DM) trials with a reported enrollment target (92% lower). The listed sponsor is Alnylam Pharmaceuticals, which has 49 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Type 2 Diabetes Mellitus (T2DM) appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT07465224 reports 1 study location spanning 1 distinct geographic area - top geographies include California.

Frequently Asked Questions

What is clinical trial NCT07465224 about?

NCT07465224 is a clinical study titled "A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus". The purpose of this study is to evaluate the effect of a single dose of ALN-4324 on whole-body insulin sensitivity in participants with T2DM

What is the current status of trial NCT07465224?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2026-01-15. Estimated completion is 2027-05-28.

What conditions does trial NCT07465224 study?

This clinical trial studies the following conditions: Type 2 Diabetes Mellitus (T2DM).

What interventions are being tested in trial NCT07465224?

The interventions under investigation include: Placebo (DRUG), ALN-4324 (DRUG).

Who is sponsoring clinical trial NCT07465224?

This trial is sponsored by Alnylam Pharmaceuticals, which has 49 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07465224 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.