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ACTIVE NOT RECRUITING Phase 2

A Study to Evaluate the Efficacy and Safety of Once-Weekly MET097 in Adults With Obesity or Overweight and T2DM

NCT06897202 · View on ClinicalTrials.gov ↗

Study Summary

This study is designed to test how well once-weekly MET097 (an ultra-long-acting GLP-1 receptor agonist) works to treat adults with obesity or overweight and type 2 diabetes mellitus (T2DM) compared to placebo. MET097 or placebo will be administered to individuals via subcutaneous injection once weekly for 28 weeks. If an individual is randomly assigned to MET097 they will receive one of four different dose regimens.

Interventions

  • DRUG Placebo
  • DRUG MET097 Injection

Study Locations (20)

California

  • Research Site US-97202-001012 — Chula Vista
  • Research Site US-97202-001019 — Los Alamitos
  • Research Site US-97202-001021 — Los Angeles
  • Research Site US-97202-001007 — Riverside

Florida

  • Research Site US-97202-001024 — Bradenton
  • Research Site 097202-001001 — Hollywood
  • Research Site 097202-001003 — Tampa

Georgia

  • Research Site 097202-001002 — Decatur
  • Research Site US-97202-001009 — Riverdale
  • Research Site 097202-001005 — Savannah

Illinois

  • Research Site US-97202-001017 — Morton
  • Research Site US-97202-001022 — Naperville

Maryland

  • Research Site US-97202-001015 — Columbia
  • Research Site US-97202-001006 — Gaithersburg

Texas

  • Research Site US-97202-001023 — Plano
  • Research Site US-97202-001013 — Sherman

Kansas

  • Research Site US-97202-001008 — Kansas City

New Jersey

  • Research Site US-97202-001004 — Marlton

Trial Details

FieldValue
Enrollment Target 133 participants
Start Date 2025-03-14
Est. Completion 2026-03
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06897202

The ClinicalTrials.gov registry entry for NCT06897202 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 133 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Metsera, a wholly owned subsidiary of Pfizer, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Type 2 Diabetes Mellitus (T2DM) appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06897202 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06897202 about?

NCT06897202 is a clinical study titled "A Study to Evaluate the Efficacy and Safety of Once-Weekly MET097 in Adults With Obesity or Overweight and T2DM". This study is designed to test how well once-weekly MET097 (an ultra-long-acting GLP-1 receptor agonist) works to treat adults with obesity or overweight and type 2 diabetes mellitus (T2DM) compared to placebo. MET097 or placebo will be administered to individuals via subcutaneous injection once wee...

What is the current status of trial NCT06897202?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 133 participants. The study started on 2025-03-14. Estimated completion is 2026-03.

What conditions does trial NCT06897202 study?

This clinical trial studies the following conditions: Type 2 Diabetes Mellitus (T2DM), Obesity in Diabetes. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06897202?

The interventions under investigation include: Placebo (DRUG), MET097 Injection (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06897202?

This trial is sponsored by Metsera, a wholly owned subsidiary of Pfizer, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06897202 being conducted?

This trial has 20 study locations across California, Florida, Georgia, Illinois, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial