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NCT07418593 · ClinicalTrials.gov registry record · Phase 4
THE Malabsorption Blood Test Trial Will Help Determine THE Benefits OF Pancreatic Enzyme Replacement Therapy IN Patients With Mild TO Moderate Exocrine Pancreatic Insufficiency.
A Phase 4 study of Chronic Pancreatitis and Exocrine Pancreatic Insufficiency, sponsored by Anna Evans Phillips.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 80
- Enrollment target
- 2
- Study locations
NCT07418593: Recruiting Phase 4 study of Chronic Pancreatitis and Exocrine Pancreatic Insufficiency, sponsored by Anna Evans Phillips.
NCT07418593 is a Phase 4 study of Chronic Pancreatitis and Exocrine Pancreatic Insufficiency that is actively recruiting participants, run by Anna Evans Phillips. The registered enrollment target is 80 participants, below the 687-participant average among 42 other Chronic Pancreatitis trials with a reported enrollment target (88% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07418593, a Phase 4 study of Chronic Pancreatitis and Exocrine Pancreatic Insufficiency, is actively recruiting participants, sponsored by Anna Evans Phillips.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 80 participants
- Enrollment target
- 2
- Study locations
Study Summary
This project uses the Malabsorption Blood Test (MBT) to identify patients with recurrent acute or chronic pancreatitis who have mild to moderate exocrine pancreatic insufficiency. A subgroup of patients who have response to pancreatic enzyme replacement therapy will enter a randomized, placebo-controlled pilot clinical trial for 8 weeks to identify improvements in quality of life (QOL).
Primary Outcome
The primary outcome of the first phase of the study will be the prevalence of responders to PERT by assessing Heptadecanoic Acid absorption following 5-days of PERT therapy compared to baseline (no PERT therapy). This will be measured by a positive area under the curve of the difference between absorption curves for Triheptadecanoic Acid and Pentadecanoic Acid.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Pancreatic Enzyme Replacement Therapy
- DIAGNOSTIC_TEST MBT1
- DIAGNOSTIC_TEST MBT 2
Study Locations (2)
Maryland
- Johns Hopkins Medicine - Baltimore
Pennsylvania
- University of Pittsburgh Medical Center - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2026-03 |
| Est. Completion | 2028-09 |
| Phase | Phase 4 |
What NCT07418593 shows while recruiting
NCT07418593 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 687-participant average among 42 other Chronic Pancreatitis trials with a reported enrollment target (88% lower).
The record links to 3 conditions, with Chronic Pancreatitis appearing as the primary indexed condition, and to 4 interventions - of which Placebo is the first listed.
NCT07418593 reports a single indexed study location in Maryland, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT07418593 about?
NCT07418593 is a clinical study titled "THE Malabsorption Blood Test Trial Will Help Determine THE Benefits OF Pancreatic Enzyme Replacement Therapy IN Patients With Mild TO Moderate Exocrine Pancreatic Insufficiency.". This project uses the Malabsorption Blood Test (MBT) to identify patients with recurrent acute or chronic pancreatitis who have mild to moderate exocrine pancreatic insufficiency. A subgroup of patients who have response to pancreatic enzyme replacement therapy will enter a randomized, placebo-contr...
What is the current status of trial NCT07418593?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 80 participants. The study started on 2026-03. Estimated completion is 2028-09.
What conditions does trial NCT07418593 study?
This clinical trial studies the following conditions: Chronic Pancreatitis, Exocrine Pancreatic Insufficiency, Recurrent Acute Pancreatitis.
What interventions are being tested in trial NCT07418593?
The interventions under investigation include: Placebo (DRUG), Pancreatic Enzyme Replacement Therapy (DRUG), MBT1 (DIAGNOSTIC_TEST), MBT 2 (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07418593?
This trial is sponsored by Anna Evans Phillips, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07418593 being conducted?
This trial has 2 study locations across Maryland, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07418593's enrollment target sits among peer trials
80 20th of 42 higher than 23 of 42 other Chronic Pancreatitis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Pancreatitis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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