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RECRUITING Phase 1

A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)

NCT07286149 · View on ClinicalTrials.gov ↗

Study Summary

Researchers want to learn if MK-1084, the study medicine, can treat advanced or metastatic non-squamous NSCLC. MK-1084 is a targeted therapy, which is a treatment that works to control how specific types of cancer cells grow and spread. The goals of this study are to learn: * About the safety of MK-1084 and if people tolerate it when taken with other treatments * How many people have the cancer respond (get smaller or go away) to the treatments

Conditions Studied

Interventions

  • BIOLOGICAL Sacituzumab tirumotecan
  • BIOLOGICAL Cetuximab
  • DRUG Rescue Medications
  • BIOLOGICAL Patritumab deruxtecan
  • DRUG MK-1084

Study Locations (3)

Other

  • Shaare Zedek Medical Center ( Site 0186) — Jerusalem
  • Severance Hospital, Yonsei University Health System ( Site 0080) — Seoul

Florida

  • Clermont Oncology Center ( Site 0041) — Clermont

Trial Details

FieldValue
Enrollment Target 190 participants
Start Date 2026-03-23
Est. Completion 2037-05-06
Phase Phase 1

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07286149

The ClinicalTrials.gov registry entry for NCT07286149 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 190 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Lung Neoplasm Malignant appearing as the primary indexed condition, and to 5 interventions — of which Sacituzumab tirumotecan is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07286149 reports 3 study locations spanning 2 distinct geographic areas — top geographies include Other, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07286149 about?

NCT07286149 is a clinical study titled "A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)". Researchers want to learn if MK-1084, the study medicine, can treat advanced or metastatic non-squamous NSCLC. MK-1084 is a targeted therapy, which is a treatment that works to control how specific types of cancer cells grow and spread. The goals of this study are to learn: * About the safety of MK...

What is the current status of trial NCT07286149?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 190 participants. The study started on 2026-03-23. Estimated completion is 2037-05-06.

What conditions does trial NCT07286149 study?

This clinical trial studies the following conditions: Lung Neoplasm Malignant. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07286149?

The interventions under investigation include: Sacituzumab tirumotecan (BIOLOGICAL), Cetuximab (BIOLOGICAL), Rescue Medications (DRUG), Patritumab deruxtecan (BIOLOGICAL), MK-1084 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07286149?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07286149 being conducted?

This trial has 3 study locations across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial