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Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)
NCT06788912 · View on ClinicalTrials.gov ↗
Study Summary
The main goals are after treatment given before surgery, to measure the number of people who have no signs of cancer cells in tumors and lymph nodes removed during surgery; and to learn about whether the cancer gets smaller or goes away by measuring the number of people with a certain number of living cancer cells in the tumor removed during surgery.
Conditions Studied
Interventions
- DRUG Cisplatin
- DRUG Pemetrexed
- DRUG Gemcitabine
- DRUG Sacituzumab tirumotecan
- BIOLOGICAL Pembrolizumab (neoadjuvant)
Study Locations (20)
Other
- Országos Korányi Pulmonológiai Intézet ( Site 0060) — Budapest
- Ospedale San Raffaele. ( Site 0171) — Milan
- Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 0175) — Milan
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 0174) — Roma
Region M. de Santiago
- Centro de Estudios Clínicos SAGA ( Site 0162) — Santiago
- FALP ( Site 0161) — Santiago
- Bradfordhill ( Site 0160) — Santiago
Attica
- Alexandra General Hospital of Athens Oncology-Hematology Unit ( Site 0203) — Athens
- ATTIKON GENERAL UNIVERSITY HOSPITAL-Oncology ( Site 0202) — Athens
- Metropolitan Hospital-4th Oncology Dept ( Site 0201) — Athens
Alabama
- Southern Cancer Center (SCC) ( Site 8004) — Daphne
California
- Sansum Clinic (Ridley Tree) ( Site 8012) — Santa Barbara
Maryland
- MedStar Franklin Square Medical Center ( Site 0033) — Baltimore
Oregon
- Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8006) — Eugene
Virginia
- Virginia Cancer Specialists (VCS) ( Site 8002) — Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-03-20 |
| Est. Completion | 2032-02-06 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06788912
The ClinicalTrials.gov registry entry for NCT06788912 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Lung Neoplasm Malignant appearing as the primary indexed condition, and to 5 interventions — of which Cisplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06788912 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Other, Region M. de Santiago, Attica. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06788912 about?
NCT06788912 is a clinical study titled "Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)". The main goals are after treatment given before surgery, to measure the number of people who have no signs of cancer cells in tumors and lymph nodes removed during surgery; and to learn about whether the cancer gets smaller or goes away by measuring the number of people with a certain number of livi...
What is the current status of trial NCT06788912?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2025-03-20. Estimated completion is 2032-02-06.
What conditions does trial NCT06788912 study?
This clinical trial studies the following conditions: Lung Neoplasm Malignant. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06788912?
The interventions under investigation include: Cisplatin (DRUG), Pemetrexed (DRUG), Gemcitabine (DRUG), Sacituzumab tirumotecan (DRUG), Pembrolizumab (neoadjuvant) (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06788912?
This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06788912 being conducted?
This trial has 20 study locations across Alabama, California, Maryland, Oregon, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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