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NCT07258485 · ClinicalTrials.gov registry record
A Study to Evaluate Sleep Electroencephalogram (EEG) Features (Brain Activity While Sleeping) in Participants With Major Depressive Disorder (MDD)
A clinical trial of Depressive Disorder, Major, sponsored by Janssen Research & Development.
- Recruiting
- Registry status
- 80
- Enrollment target
- 14
- Study locations
NCT07258485: Recruiting study of Depressive Disorder, Major, sponsored by Janssen Research & Development.
NCT07258485 is a study of Depressive Disorder, Major that is actively recruiting participants, run by Janssen Research & Development. The registered enrollment target is 80 participants, below the 241-participant average among 52 other Depressive Disorder, Major trials with a reported enrollment target (67% lower). The trial reports 14 study locations across 9 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07258485, a study of Depressive Disorder, Major, is actively recruiting participants, sponsored by Janssen Research & Development.
- RECRUITING
- Registry status
- 80 participants
- Enrollment target
- 14
- Study locations
Study Summary
The purpose of this study is to evaluate sleep in participants with Major Depressive Disorder with moderate to severe insomnia symptoms (MDDIS) or MDD with no or mild insomnia symptoms (non-MDDIS), using an at-home sleep Electroencephalogram (EEG; a device that records brain activity during sleep). The study also aims to examine the association between objective sleep EEG features (measured using devices) and subjective sleep measures (self-reported experiences, such as how a person feels about their sleep) in participants with MDDIS or non-MDDIS.
Primary Outcome
Objective sleep EEG features in MDD participants will be assessed using dreem 3S headband. It will be used in this study to capture macro and micro sleep architecture including sleep initiation (latent to persistent sleep, sleep onset latency), sleep maintenance (rapid eye movement \[REM\] latency, total sleep time, REM percentage, and duration) and arousal features (stage shift index, number of awakenings). It also uses a 3D accelerometer to measure movements, head position, and respiratory rat
Conditions Studied
Study Locations (14)
California
- Behavioral Research Specialists LLC - Glendale
- Pacific Clinical Research Medical Group - Upland
- Sunwise Clinical Research - Walnut Creek
Florida
- Velocity Clinical Research - Hallandale
- Meridian International Research - Miami Gardens
Massachusetts
- Adams Clinical - Boston
- Adams Clinical - Watertown
New York
- Adams Clinical - New York
- Adams Clinical - The Bronx
Illinois
- IMA Clinical Research PC - Chicago
Pennsylvania
- Adams Clinical - Philadelphia
Texas
- Adams Clinical - DeSoto
Utah
- Inner Space Research LLC - Orem
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2025-11-24 |
| Est. Completion | 2026-04-24 |
What NCT07258485 shows while recruiting
NCT07258485 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 241-participant average among 52 other Depressive Disorder, Major trials with a reported enrollment target (67% lower).
The record links to 1 condition, with Depressive Disorder, Major appearing as the primary indexed condition, and to 0 interventions.
NCT07258485 lists 14 locations in 9 states (California, Florida, Massachusetts).
Frequently Asked Questions
What is clinical trial NCT07258485 about?
NCT07258485 is a clinical study titled "A Study to Evaluate Sleep Electroencephalogram (EEG) Features (Brain Activity While Sleeping) in Participants With Major Depressive Disorder (MDD)". The purpose of this study is to evaluate sleep in participants with Major Depressive Disorder with moderate to severe insomnia symptoms (MDDIS) or MDD with no or mild insomnia symptoms (non-MDDIS), using an at-home sleep Electroencephalogram (EEG; a device that records brain activity during sleep). ...
What is the current status of trial NCT07258485?
This trial is currently recruiting. The enrollment target is 80 participants. The study started on 2025-11-24. Estimated completion is 2026-04-24.
What conditions does trial NCT07258485 study?
This clinical trial studies the following conditions: Depressive Disorder, Major.
Who is sponsoring clinical trial NCT07258485?
This trial is sponsored by Janssen Research & Development, which has 593 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07258485 being conducted?
This trial has 14 study locations across California, Florida, Illinois, Massachusetts, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depressive Disorder, Major
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07258485's enrollment target sits among peer trials
80 31st of 52 higher than 21 of 52 other Depressive Disorder, Major trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depressive Disorder, Major trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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