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NCT07121582 · ClinicalTrials.gov registry record · NA
Modulation of Brain Rhythms in Stroke
A NA study of Stroke, sponsored by University of North Carolina, Chapel Hill.
- Recruiting
- Registry status
- NA
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT07121582: Recruiting NA study of Stroke, sponsored by University of North Carolina, Chapel Hill.
NCT07121582 is a NA study of Stroke that is actively recruiting participants, run by University of North Carolina, Chapel Hill. The registered enrollment target is 20 participants, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07121582, a NA study of Stroke, is actively recruiting participants, sponsored by University of North Carolina, Chapel Hill.
- RECRUITING
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this research study is to examine communication between brain and muscle in individuals with stroke and determine if applying non-invasive brain stimulation to different parts of the brain improves this communication and performance on a hand squeezing task. The investigators will fit participants with an electroencephalography (EEG) cap and place electromyography (EMG) stickers on participants hand and arm muscles to record brain and muscle activity, respectively. Participants will complete a single research visit lasting approximately 3 hours. During this visit, participants will receive two different types of non-invasive brain stimulation: \[1\] stimulation to the motor part of the brain and \[2\] stimulation to the visual part of the brain. Participants will be randomized so that half will receive stimulation to the motor part of the brain first followed by stimulation to the visual part of the brain second and vice versa. Participants will complete three blocks of hand squeezing trials using the stroke-affected (weak) hand. During the first block of squeezing trials, no brain stimulation will occur. During the second and third blocks, participants will receive stimulation just before each hand squeezing trial. The investigators will record participants' brain and muscle activity during these blocks of hand squeezing trials. Additionally, participants will also complete screening tests and exams looking at mood, motor function, and cognition.
Primary Outcome
Investigators will compute pre/post changes in brain-muscle functional connectivity (i.e., corticomuscular coherence, CMC) following across each block (20 trials/block). Specifically, investigators are focused on CMC in the beta (13-30 Hz) frequency range between the ipsilesional motor cortex (M1) and the affected first dorsal interossei muscle. Investigators will calculate CMC at two distinct phases during the squeezing task that correspond to the ramp/recruitment phase (i.e., squeezing to the
Conditions Studied
Interventions
- OTHER Motor Brain Stimulation
- OTHER Visual Brain Stimulation
Study Locations (1)
North Carolina
- Bondurant Hall - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-12-01 |
| Est. Completion | 2027-01 |
| Phase | NA |
What NCT07121582 shows while recruiting
NCT07121582 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Stroke appearing as the primary indexed condition, and to 2 interventions - of which Motor Brain Stimulation is the first listed.
NCT07121582 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT07121582 about?
NCT07121582 is a clinical study titled "Modulation of Brain Rhythms in Stroke". The goal of this research study is to examine communication between brain and muscle in individuals with stroke and determine if applying non-invasive brain stimulation to different parts of the brain improves this communication and performance on a hand squeezing task. The investigators will fit p...
What is the current status of trial NCT07121582?
This trial is currently recruiting. It is a NA study. The enrollment target is 20 participants. The study started on 2025-12-01. Estimated completion is 2027-01.
What conditions does trial NCT07121582 study?
This clinical trial studies the following conditions: Stroke.
What interventions are being tested in trial NCT07121582?
The interventions under investigation include: Motor Brain Stimulation (OTHER), Visual Brain Stimulation (OTHER).
Who is sponsoring clinical trial NCT07121582?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07121582 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Stroke
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07121582's enrollment target sits among peer trials
20 361st of 454 higher than 74 of 454 other Stroke trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stroke trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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