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NCT07107230 · ClinicalTrials.gov registry record · Phase 1

A Study of JNJ-95437446 in Participants With Advanced-Stage Solid Tumors

A Phase 1 study of Colorectal Neoplasms, sponsored by Janssen Research & Development.

Recruiting
Registry status
Phase 1
Development phase
380
Enrollment target
8
Study locations

NCT07107230 is a Phase 1 study of Colorectal Neoplasms that is actively recruiting participants, run by Janssen Research & Development. The registered enrollment target is 380 participants, below the 569-participant average among 54 other Colorectal Neoplasms trials with a reported enrollment target (33% lower). The trial reports 8 study locations across 3 states.

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The verdict

NCT07107230, a Phase 1 study of Colorectal Neoplasms, is actively recruiting participants, sponsored by Janssen Research & Development.

RECRUITING
Registry status
Phase 1
Development phase
380 participants
Enrollment target
8
Study locations

Study Summary

The purpose of this study is to determine recommended phase 2 doses (RP2Ds) of JNJ-95437446 in Part 1, and to further evaluate the safety of the RP2Ds in participants with advanced solid tumors in Part 2.

Conditions Studied

Colorectal Neoplasms

Interventions

  • DRUG JNJ-95437446

Study Locations (8)

Other

  • Severance Hospital Yonsei University Health System - Seoul
  • Samsung Medical Center - Seoul
  • Hosp Univ Vall D Hebron - Barcelona
  • Hosp Univ Fund Jimenez Diaz - Madrid
  • Hosp. Univ. 12 de Octubre - Madrid
  • Hosp Univ Hm Sanchinarro - Madrid

Florida

  • Florida Cancer Specialists - Sarasota

Virginia

  • NEXT Oncology - Fairfax

Trial Details

FieldValue
Enrollment Target 380 participants
Start Date 2025-07-15
Est. Completion 2028-04-24
Phase Phase 1

Sponsor

Janssen Research & Development

593 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07107230

The ClinicalTrials.gov registry entry for NCT07107230 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 380 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 569-participant average among 54 other Colorectal Neoplasms trials with a reported enrollment target (33% lower). The listed sponsor is Janssen Research & Development, which has 593 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Colorectal Neoplasms appearing as the primary indexed condition, and to 1 intervention - of which JNJ-95437446 is the first listed.

NCT07107230 reports 8 study locations spanning 3 distinct geographic areas - top geographies include Other, Florida, Virginia.

Frequently Asked Questions

What is clinical trial NCT07107230 about?

NCT07107230 is a clinical study titled "A Study of JNJ-95437446 in Participants With Advanced-Stage Solid Tumors". The purpose of this study is to determine recommended phase 2 doses (RP2Ds) of JNJ-95437446 in Part 1, and to further evaluate the safety of the RP2Ds in participants with advanced solid tumors in Part 2.

What is the current status of trial NCT07107230?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 380 participants. The study started on 2025-07-15. Estimated completion is 2028-04-24.

What conditions does trial NCT07107230 study?

This clinical trial studies the following conditions: Colorectal Neoplasms.

What interventions are being tested in trial NCT07107230?

The interventions under investigation include: JNJ-95437446 (DRUG).

Who is sponsoring clinical trial NCT07107230?

This trial is sponsored by Janssen Research & Development, which has 593 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07107230 being conducted?

This trial has 8 study locations across Florida, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.