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NCT07099950 · ClinicalTrials.gov registry record · NA
Dose-Dependent Effects of Low-Intensity Focused Ultrasound
A NA study of Healthy (Controls), sponsored by Laureate Institute for Brain Research.
- Recruiting
- Registry status
- NA
- Development phase
- 66
- Enrollment target
- 1
- Study location
NCT07099950: Recruiting NA study of Healthy (Controls), sponsored by Laureate Institute for Brain Research.
NCT07099950 is a NA study of Healthy (Controls) that is actively recruiting participants, run by Laureate Institute for Brain Research. The registered enrollment target is 66 participants, below the 117-participant average among 16 other Healthy (Controls) trials with a reported enrollment target (44% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07099950, a NA study of Healthy (Controls), is actively recruiting participants, sponsored by Laureate Institute for Brain Research.
- RECRUITING
- Registry status
- NA
- Development phase
- 66 participants
- Enrollment target
- 1
- Study location
Study Summary
Low-intensity focused ultrasound (LIFU) has emerged as a tool to modulate the activity of deep brain structures noninvasively and reversibly, with anatomical precision. Following the results of a pilot study in which the investigators observed target engagement when LIFU was applied to the anterior limb of the internal capsule, the investigators now propose to determine the dose-response relationships of LIFU when applied to deep white matter tracts of the human brain. The investigators hope a successful study will be rapidly translatable into clinical trials seeking to understand mechanistic brain circuit-symptom relationships in major psychiatric disorders.
Primary Outcome
Changes in resting-state functional (fMRI) connectivity (FC) between thalamus and both subgenual (sgCC) and orbitofrontal (OFC) cortices after one vs. after three-epoch LIFU.
Conditions Studied
Interventions
- OTHER Low-intensity focused ultrasound
Study Locations (1)
Oklahoma
- Laureate Institute for Brain Research - Tulsa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2025-04-22 |
| Est. Completion | 2026-12 |
| Phase | NA |
What NCT07099950 shows while recruiting
NCT07099950 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, below the 117-participant average among 16 other Healthy (Controls) trials with a reported enrollment target (44% lower).
The record links to 1 condition, with Healthy (Controls) appearing as the primary indexed condition, and to 1 intervention - of which Low-intensity focused ultrasound is the first listed.
NCT07099950 reports a single indexed study location in Oklahoma.
Frequently Asked Questions
What is clinical trial NCT07099950 about?
NCT07099950 is a clinical study titled "Dose-Dependent Effects of Low-Intensity Focused Ultrasound". Low-intensity focused ultrasound (LIFU) has emerged as a tool to modulate the activity of deep brain structures noninvasively and reversibly, with anatomical precision. Following the results of a pilot study in which the investigators observed target engagement when LIFU was applied to the anterior ...
What is the current status of trial NCT07099950?
This trial is currently recruiting. It is a NA study. The enrollment target is 66 participants. The study started on 2025-04-22. Estimated completion is 2026-12.
What conditions does trial NCT07099950 study?
This clinical trial studies the following conditions: Healthy (Controls).
What interventions are being tested in trial NCT07099950?
The interventions under investigation include: Low-intensity focused ultrasound (OTHER).
Who is sponsoring clinical trial NCT07099950?
This trial is sponsored by Laureate Institute for Brain Research, which has 45 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07099950 being conducted?
This trial has 1 study location across Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy (Controls)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07099950's enrollment target sits among peer trials
66 10th of 16 higher than 7 of 16 other Healthy (Controls) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy (Controls) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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