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NCT07221864 · ClinicalTrials.gov registry record · NA
Decoding Emotional Dynamics in Bipolar Disorder
A NA study of Healthy (Controls) and Bipolar Disorder I or II, sponsored by Laureate Institute for Brain Research.
- Recruiting
- Registry status
- NA
- Development phase
- 72
- Enrollment target
- 1
- Study location
NCT07221864: Recruiting NA study of Healthy (Controls) and Bipolar Disorder I or II, sponsored by Laureate Institute for Brain Research.
NCT07221864 is a NA study of Healthy (Controls) and Bipolar Disorder I or II that is actively recruiting participants, run by Laureate Institute for Brain Research. The registered enrollment target is 72 participants, below the 117-participant average among 16 other Healthy (Controls) trials with a reported enrollment target (38% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07221864, a NA study of Healthy (Controls) and Bipolar Disorder I or II, is actively recruiting participants, sponsored by Laureate Institute for Brain Research.
- RECRUITING
- Registry status
- NA
- Development phase
- 72 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this neuroimaging study is to investigate how emotional states fluctuate in people with bipolar disorder (BD) compared to healthy controls, and to understand the neural mechanisms driving mood instability. The main questions it aims to answer are: * Can emotional states be decoded from fMRI brain activity using machine learning? * Do individuals with BD show more unstable emotional state trajectories (e.g., high metastability, low fractal scaling) than healthy controls? * Does amplifying positive emotions stabilize brain and emotional dynamics in BD? Researchers will compare individuals with bipolar disorder (BD-I or BD-II, currently depressed or mixed state) to healthy controls without psychiatric history to see whether the BD group shows greater fluctuations in emotional brain activity and whether positive emotion regulation strategies normalize this instability. Participants will: * Complete self-report questionnaires on mood, emotion regulation, anxiety, and daily functioning. * Recall and provide short descriptions of personal positive and negative memories to be used in the MRI task. * Undergo fMRI scanning, including: * Resting-state scans * A Think and Regulate Affective States Task (TReAT) where they recall autobiographical memories, rate emotions, and practice amplifying positive mood. * Structural and diffusion MRI for brain mapping. * Receive physiological monitoring (heart rate, respiration) during scanning. * Complete post-scan surveys on emotional state and task experience. This research will help clarify how the brain supports or disrupts emotional regulation in bipolar disorder and may inform the development of personalized, neurobiologically informed treatments for mood instability.
Primary Outcome
The decoded emotional state time course derived from fMRI during the Think and Regulate Affective States Task (TReAT). Temporal irregularity will be quantified using permutation entropy to assess emotional state instability in individuals with bipolar disorder compared to healthy controls.
Conditions Studied
Interventions
- BEHAVIORAL Think and Regulate Affective State Task
Study Locations (1)
Oklahoma
- Laureate Institute for Brain Research - Tulsa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 72 participants |
| Start Date | 2025-11 |
| Est. Completion | 2028-11 |
| Phase | NA |
What NCT07221864 shows while recruiting
NCT07221864 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 72 participants, a relatively small participant target, below the 117-participant average among 16 other Healthy (Controls) trials with a reported enrollment target (38% lower).
The record links to 2 conditions, with Healthy (Controls) appearing as the primary indexed condition, and to 1 intervention - of which Think and Regulate Affective State Task is the first listed.
NCT07221864 reports a single indexed study location in Oklahoma.
Frequently Asked Questions
What is clinical trial NCT07221864 about?
NCT07221864 is a clinical study titled "Decoding Emotional Dynamics in Bipolar Disorder". The goal of this neuroimaging study is to investigate how emotional states fluctuate in people with bipolar disorder (BD) compared to healthy controls, and to understand the neural mechanisms driving mood instability. The main questions it aims to answer are: * Can emotional states be decoded from ...
What is the current status of trial NCT07221864?
This trial is currently recruiting. It is a NA study. The enrollment target is 72 participants. The study started on 2025-11. Estimated completion is 2028-11.
What conditions does trial NCT07221864 study?
This clinical trial studies the following conditions: Healthy (Controls), Bipolar Disorder I or II.
What interventions are being tested in trial NCT07221864?
The interventions under investigation include: Think and Regulate Affective State Task (BEHAVIORAL).
Who is sponsoring clinical trial NCT07221864?
This trial is sponsored by Laureate Institute for Brain Research, which has 45 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07221864 being conducted?
This trial has 1 study location across Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy (Controls)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07221864's enrollment target sits among peer trials
72 9th of 16 higher than 8 of 16 other Healthy (Controls) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy (Controls) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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