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NCT06607432 · ClinicalTrials.gov registry record · NA
Temporal Interference Stimulation for Social Cognition
A NA study of Healthy (Controls), sponsored by Columbia University.
- Recruiting
- Registry status
- NA
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT06607432: Recruiting NA study of Healthy (Controls), sponsored by Columbia University.
NCT06607432 is a NA study of Healthy (Controls) that is actively recruiting participants, run by Columbia University. The registered enrollment target is 30 participants, below the 119-participant average among 16 other Healthy (Controls) trials with a reported enrollment target (75% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06607432, a NA study of Healthy (Controls), is actively recruiting participants, sponsored by Columbia University.
- RECRUITING
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
The long-term goal of this project is to evaluate whether a procedure termed transcranial interference stimulation (tIS) may be useful in the future in the treatment of severe neuropsychiatric disorders such as schizophrenia. The purpose of this stage of the project is to evaluate the safety and tolerability of tIS administration in healthy volunteers. This study involves 30 healthy participants without known psychiatric illness, who will participate in groups of 10. The dose of tIS will be escalated progressively across doses. Functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS) and side effect checklists will be used to assess tIS safety/tolerability at each dose. In addition, electroencephalogram (EEG) will be collected simultaneously with tIS and used to assess target engagement. Face emotion recognition (FER) data will also be collected, but will be used for feasibility assessment only. If successful, these studies will form the basis for future studies in schizophrenia.
Primary Outcome
Pulvinar nucleus (PuN) activation levels as determined by functional magnetic resonance imaging (fMRI, safety) These analyses assess the degree to which presentation of a stimulus designed to activate the pulvinar nucleus leads to an increase in local activation as reflected in the fMRI response. Units will be % increase in signal strength during stimulation vs. baseline.
Conditions Studied
Interventions
- DEVICE Transcranial Interference Stimulation (tIS)
- OTHER Sham tIS
Study Locations (1)
New York
- Columbia University Irving Medical Center/NewYork-Presbyterian Hospital (CUIMC/NYPH) - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2025-03-03 |
| Est. Completion | 2028-02-29 |
| Phase | NA |
What NCT06607432 shows while recruiting
NCT06607432 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 119-participant average among 16 other Healthy (Controls) trials with a reported enrollment target (75% lower).
The record links to 1 condition, with Healthy (Controls) appearing as the primary indexed condition, and to 2 interventions - of which Transcranial Interference Stimulation (tIS) is the first listed.
NCT06607432 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT06607432 about?
NCT06607432 is a clinical study titled "Temporal Interference Stimulation for Social Cognition". The long-term goal of this project is to evaluate whether a procedure termed transcranial interference stimulation (tIS) may be useful in the future in the treatment of severe neuropsychiatric disorders such as schizophrenia. The purpose of this stage of the project is to evaluate the safety and tol...
What is the current status of trial NCT06607432?
This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2025-03-03. Estimated completion is 2028-02-29.
What conditions does trial NCT06607432 study?
This clinical trial studies the following conditions: Healthy (Controls).
What interventions are being tested in trial NCT06607432?
The interventions under investigation include: Transcranial Interference Stimulation (tIS) (DEVICE), Sham tIS (OTHER).
Who is sponsoring clinical trial NCT06607432?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06607432 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy (Controls)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06607432's enrollment target sits among peer trials
30 15th of 16 higher than 2 of 16 other Healthy (Controls) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy (Controls) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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