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NCT07095712 · ClinicalTrials.gov registry record · Phase 1
Personalized Antisense Oligonucleotide Therapy for A Single Participant With TARDBP ALS
A Phase 1 study of Amyotrophic Lateral Sclerosis, sponsored by n-Lorem Foundation.
- Active
- Registry status
- Phase 1
- Development phase
- 1
- Enrollment target
- 2
- Study locations
NCT07095712: Active Phase 1 study of Amyotrophic Lateral Sclerosis, sponsored by n-Lorem Foundation.
NCT07095712 is a Phase 1 study of Amyotrophic Lateral Sclerosis that is active but no longer recruiting, run by n-Lorem Foundation. The registered enrollment target is 1 participants, below the 898-participant average among 102 other Amyotrophic Lateral Sclerosis trials with a reported enrollment target (100% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07095712, a Phase 1 study of Amyotrophic Lateral Sclerosis, is active but no longer recruiting, sponsored by n-Lorem Foundation.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 1 participants
- Enrollment target
- 2
- Study locations
Study Summary
This research project entails delivery of a personalized antisense oligonucleotide (ASO) drug designed for a single participant with amyotrophic lateral sclerosis (ALS) due to a pathogenic variant in TARDBP.
Primary Outcome
Change from baseline at 12-months post nL-TARD-001 administration in scores on Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R).
Conditions Studied
Interventions
- DRUG nL-TARD-001
Study Locations (2)
New York
- Columbia University, Irving Medical Center - New York
Texas
- Houston Methodist - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1 participants |
| Start Date | 2024-11-25 |
| Est. Completion | 2025-11 |
| Phase | Phase 1 |
What the registry record for NCT07095712 still lists
NCT07095712 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 1 participants, a relatively small participant target, below the 898-participant average among 102 other Amyotrophic Lateral Sclerosis trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Amyotrophic Lateral Sclerosis appearing as the primary indexed condition, and to 1 intervention - of which nL-TARD-001 is the first listed.
NCT07095712 reports a single indexed study location in New York, Texas.
Frequently Asked Questions
What is clinical trial NCT07095712 about?
NCT07095712 is a clinical study titled "Personalized Antisense Oligonucleotide Therapy for A Single Participant With TARDBP ALS". This research project entails delivery of a personalized antisense oligonucleotide (ASO) drug designed for a single participant with amyotrophic lateral sclerosis (ALS) due to a pathogenic variant in TARDBP.
What is the current status of trial NCT07095712?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 1 participants. The study started on 2024-11-25. Estimated completion is 2025-11.
What conditions does trial NCT07095712 study?
This clinical trial studies the following conditions: Amyotrophic Lateral Sclerosis.
What interventions are being tested in trial NCT07095712?
The interventions under investigation include: nL-TARD-001 (DRUG).
Who is sponsoring clinical trial NCT07095712?
This trial is sponsored by n-Lorem Foundation, which has 12 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07095712 being conducted?
This trial has 2 study locations across New York, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Amyotrophic Lateral Sclerosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07095712's enrollment target sits among peer trials
1 101st of 102 the lowest of 102 other Amyotrophic Lateral Sclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Amyotrophic Lateral Sclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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