Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07044596 · ClinicalTrials.gov registry record · NA
Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline
A NA study of Mild Traumatic Brain Injury and Post-Concussion Syndrome, sponsored by University of Wisconsin, Madison.
- Recruiting
- Registry status
- NA
- Development phase
- 55
- Enrollment target
- 1
- Study location
NCT07044596: Recruiting NA study of Mild Traumatic Brain Injury and Post-Concussion Syndrome, sponsored by University of Wisconsin, Madison.
NCT07044596 is a NA study of Mild Traumatic Brain Injury and Post-Concussion Syndrome that is actively recruiting participants, run by University of Wisconsin, Madison. The registered enrollment target is 55 participants, below the 219-participant average among 43 other Mild Traumatic Brain Injury trials with a reported enrollment target (75% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07044596, a NA study of Mild Traumatic Brain Injury and Post-Concussion Syndrome, is actively recruiting participants, sponsored by University of Wisconsin, Madison.
- RECRUITING
- Registry status
- NA
- Development phase
- 55 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain. The modulated blood flow will restore the flow of cerebrospinal fluid (CSF) and this in turn can help improve waste clearance in the brain and prevent build up that may lead to disease.
Primary Outcome
The fNIRS device will record changes in the blood oxygen level in the brain that is caused by the V1 stimulation.
Conditions Studied
Interventions
- DEVICE Magnetic Resonance Imaging (MRI)
- DEVICE Functional near-infrared spectroscopy (fNIRS)
- DEVICE V1 stimulation electrodes
Study Locations (1)
Wisconsin
- University of Wisconsin - Madison - Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 55 participants |
| Start Date | 2025-11-13 |
| Est. Completion | 2026-08 |
| Phase | NA |
What NCT07044596 shows while recruiting
NCT07044596 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 55 participants, a relatively small participant target, below the 219-participant average among 43 other Mild Traumatic Brain Injury trials with a reported enrollment target (75% lower).
The record links to 2 conditions, with Mild Traumatic Brain Injury appearing as the primary indexed condition, and to 3 interventions - of which Magnetic Resonance Imaging (MRI) is the first listed.
NCT07044596 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT07044596 about?
NCT07044596 is a clinical study titled "Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline". The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain. The modulated blood flow will restore the flow of cerebrospinal fluid (CSF) and this in turn can help improve waste clearance in the brain and prevent ...
What is the current status of trial NCT07044596?
This trial is currently recruiting. It is a NA study. The enrollment target is 55 participants. The study started on 2025-11-13. Estimated completion is 2026-08.
What conditions does trial NCT07044596 study?
This clinical trial studies the following conditions: Mild Traumatic Brain Injury, Post-Concussion Syndrome.
What interventions are being tested in trial NCT07044596?
The interventions under investigation include: Magnetic Resonance Imaging (MRI) (DEVICE), Functional near-infrared spectroscopy (fNIRS) (DEVICE), V1 stimulation electrodes (DEVICE).
Who is sponsoring clinical trial NCT07044596?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07044596 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mild Traumatic Brain Injury
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07044596's enrollment target sits among peer trials
55 33rd of 43 higher than 10 of 43 other Mild Traumatic Brain Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mild Traumatic Brain Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Concussion Recovery and Support Program
RECRUITING · NA
-
Vestibular Rehabilitation App for Adults With Dizziness Related to mTBI
RECRUITING · NA
-
Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
RECRUITING · NA
-
Passive Neurosensory Reintegration Training as a Tool to Augment Mild Traumatic Brain Injury
RECRUITING · NA
-
Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms
RECRUITING · NA
-
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01638676 · 55 participants · Phase 1
A Phase I/II Trial of Vemurafenib and Metformin to Melanoma Patients
- NCT01906385 · 55 participants · Phase 1
Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)
- NCT03007030 · 55 participants · Phase 2
Brentuximab Vedotin in Treating Patients With CD30+ Malignant Mesothelioma That Cannot Be Removed by Surgery
- NCT03152058 · 55 participants · Phase 2
IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI