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NCT07017946 · ClinicalTrials.gov registry record · Phase 1
Intestinal Microbiome Transplant in ALS
A Phase 1 study of Amyotrophic Lateral Sclerosis (ALS), sponsored by Duke University.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT07017946: Recruiting Phase 1 study of Amyotrophic Lateral Sclerosis (ALS), sponsored by Duke University.
NCT07017946 is a Phase 1 study of Amyotrophic Lateral Sclerosis (ALS) that is actively recruiting participants, run by Duke University. The registered enrollment target is 20 participants, below the 301-participant average among 18 other Amyotrophic Lateral Sclerosis (ALS) trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07017946, a Phase 1 study of Amyotrophic Lateral Sclerosis (ALS), is actively recruiting participants, sponsored by Duke University.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a 24-week study of intestinal microbiome transplant in people with ALS. All participants will be evaluated clinically in person for 4 visits. Blood and mailed/ fresh stool samples will also be collected. Blood samples will be used to determine changes in neurofilament light chain over time. Stool samples will be processed for microbiome analysis. Participants will have phone visits to further evaluate safety and tolerability. They will then undergo antibiotic conditioning and a standard bowel preparation before being assigned to the investigational product, MTP-101C .
Primary Outcome
The ALSFRS-R is a quickly administered (five minute) ordinal rating scale (ratings 0-4) used to determine patients' assessments of their capability and independence in 12 functional activities. The total score ranges from 0 to 48, where higher scores indicate better function.
Conditions Studied
Interventions
- DRUG MTP-101C
Study Locations (1)
North Carolina
- Duke University Medical Center - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-01-27 |
| Est. Completion | 2026-11-01 |
| Phase | Phase 1 |
What NCT07017946 shows while recruiting
NCT07017946 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 301-participant average among 18 other Amyotrophic Lateral Sclerosis (ALS) trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Amyotrophic Lateral Sclerosis (ALS) appearing as the primary indexed condition, and to 1 intervention - of which MTP-101C is the first listed.
NCT07017946 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT07017946 about?
NCT07017946 is a clinical study titled "Intestinal Microbiome Transplant in ALS". This is a 24-week study of intestinal microbiome transplant in people with ALS. All participants will be evaluated clinically in person for 4 visits. Blood and mailed/ fresh stool samples will also be collected. Blood samples will be used to determine changes in neurofilament light chain over time. ...
What is the current status of trial NCT07017946?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2026-01-27. Estimated completion is 2026-11-01.
What conditions does trial NCT07017946 study?
This clinical trial studies the following conditions: Amyotrophic Lateral Sclerosis (ALS).
What interventions are being tested in trial NCT07017946?
The interventions under investigation include: MTP-101C (DRUG).
Who is sponsoring clinical trial NCT07017946?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07017946 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Amyotrophic Lateral Sclerosis (ALS)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07017946's enrollment target sits among peer trials
20 17th of 18 higher than 2 of 18 other Amyotrophic Lateral Sclerosis (ALS) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Amyotrophic Lateral Sclerosis (ALS) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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