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NCT07187388 · ClinicalTrials.gov registry record · NA
Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.
A NA study of Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS), sponsored by Nova Southeastern University.
- Recruiting
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT07187388: Recruiting NA study of Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS), sponsored by Nova Southeastern University.
NCT07187388 is a NA study of Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS) that is actively recruiting participants, run by Nova Southeastern University. The registered enrollment target is 10 participants, below the 302-participant average among 18 other Amyotrophic Lateral Sclerosis (ALS) trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07187388, a NA study of Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS), is actively recruiting participants, sponsored by Nova Southeastern University.
- RECRUITING
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to evaluate the impact of non-invasive electrical stimulation, when placed on the facial muscles can reduce facial pain and improve jaw mobility, and chewing in individuals with Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS). The secondary goal is to evaluate the impact of non-invasive electrical stimulation on patient reported difficulty performing oral hygiene tasks in individuals with ALS and PLS. Participants will attend one in-person clinic visit and participate in one telephone interview 24 hours after the treatment. The clinic visit will include pre-intervention assessments, a single 30-minute treatment of electrical stimulation followed by post-intervention assessments. The assessments will include a self-rating of jaw and facial pain, a range of motion test where participants will be asked to open their jaw as wide and as far to the side as possible, and a chewing efficiency test using a saltine cracker. Twenty-four hours later, participants will receive a follow-up phone call to self-rate their facial pain and report any difficulty performing oral hygiene tasks. The treatment consists of a single 30-minute electrical stimulation session. Electrode pads will be placed on the participant's facial region, specifically over the masseter muscle belly and the TMJ area, while the participant is seated comfortably. The pads will be connected to an FDA-approved electrical stimulator, and the current will be adjusted to the participant's comfort level. Once set, the participant will remain seated for 30 minutes. At the end of the session, the stimulator will be turned off and the electrode pads removed.
Primary Outcome
0-10 numeric rating scale where participants will self rate their pain on a scale of 0-10 with 0 = no pain and 10 = worst possible pain.
Conditions Studied
Interventions
- DEVICE Transcutaneous Electrical Nerve Stimulation to reduce facial pain and improve jaw range of motion in ALS and PLS
Study Locations (1)
Florida
- Nova Southeastern University, David and Cathy Husman Neuroscience Institute - Davie
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2026-01-30 |
| Est. Completion | 2026-08-13 |
| Phase | NA |
What NCT07187388 shows while recruiting
NCT07187388 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 302-participant average among 18 other Amyotrophic Lateral Sclerosis (ALS) trials with a reported enrollment target (97% lower).
The record links to 3 conditions, with Amyotrophic Lateral Sclerosis (ALS) appearing as the primary indexed condition, and to 1 intervention - of which Transcutaneous Electrical Nerve Stimulation to reduce facial pain and improve jaw range of motion in ALS and PLS is the first listed.
NCT07187388 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT07187388 about?
NCT07187388 is a clinical study titled "Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.". The goal of this clinical trial is to evaluate the impact of non-invasive electrical stimulation, when placed on the facial muscles can reduce facial pain and improve jaw mobility, and chewing in individuals with Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS). The secondary ...
What is the current status of trial NCT07187388?
This trial is currently recruiting. It is a NA study. The enrollment target is 10 participants. The study started on 2026-01-30. Estimated completion is 2026-08-13.
What conditions does trial NCT07187388 study?
This clinical trial studies the following conditions: Amyotrophic Lateral Sclerosis (ALS), Primary Lateral Sclerosis (PLS), Motor Neuron Disease, Amyotrophic Lateral Sclerosis.
What interventions are being tested in trial NCT07187388?
The interventions under investigation include: Transcutaneous Electrical Nerve Stimulation to reduce facial pain and improve jaw range of motion in ALS and PLS (DEVICE).
Who is sponsoring clinical trial NCT07187388?
This trial is sponsored by Nova Southeastern University, which has 71 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07187388 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Amyotrophic Lateral Sclerosis (ALS)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07187388's enrollment target sits among peer trials
10 19th of 18 the lowest of 18 other Amyotrophic Lateral Sclerosis (ALS) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Amyotrophic Lateral Sclerosis (ALS) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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