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RECRUITING Phase 3

REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults

NCT07015905 · View on ClinicalTrials.gov ↗

Study Summary

This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing Venous Thromboembolism (VTE) and other related diseases after total knee replacement surgery. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)

Interventions

  • DRUG Placebo
  • DRUG Apixaban
  • DRUG REGN7508
  • DRUG Enoxaparin

Study Locations (20)

Florida

  • Delray Physician Care Center — Delray Beach
  • Bioresearch Partner — Miami
  • Sacred Heart Health System Inc — Pensacola
  • Gulfcoast Research Institute — Sarasota
  • Phoenix Clinical Research — Tamarac

Texas

  • HD Research - First Surgical Hospital — Bellaire
  • University of Texas (UT); Southwestern Medical Center — Dallas
  • NextStage Clinical Research, All American Orthopedics and Sports Medicine — Houston
  • Futuro Clinical Trials — McAllen
  • Flourish Research - San Antonio (Formerly Clinical Trials of Texas) — San Antonio

Other

  • Multi-profile Hospital for Active Treatment Hearth and Brain EAD — Pleven
  • Multiprofile Hospital for Active Treatment; Sveta Sofia EOOD (MBAL Sveta Sofia), — Sofia

Alabama

  • Shoals Medical Trials, Inc. — Sheffield

California

  • CARI Clinical Trials — Riverside

Colorado

  • Denver Metro Orthopedics, P.C. Englewood Location — Englewood

Maryland

  • Sinai Hospital of Baltimore, Inc. — Baltimore

Massachusetts

  • Brigham and Women's Hospital — Boston

Trial Details

FieldValue
Enrollment Target 2,000 participants
Start Date 2025-06-25
Est. Completion 2027-05-12
Phase Phase 3

Sponsor

Regeneron Pharmaceuticals

290 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07015905

The ClinicalTrials.gov registry entry for NCT07015905 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 2,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Regeneron Pharmaceuticals, which has 290 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Venous Thromboembolism (VTE) appearing as the primary indexed condition, and to 4 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07015905 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Florida, Texas, Other. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07015905 about?

NCT07015905 is a clinical study titled "REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults". This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing Venous Thromboembolism (VTE) a...

What is the current status of trial NCT07015905?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 2,000 participants. The study started on 2025-06-25. Estimated completion is 2027-05-12.

What conditions does trial NCT07015905 study?

This clinical trial studies the following conditions: Venous Thromboembolism (VTE). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07015905?

The interventions under investigation include: Placebo (DRUG), Apixaban (DRUG), REGN7508 (DRUG), Enoxaparin (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07015905?

This trial is sponsored by Regeneron Pharmaceuticals, which has 290 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07015905 being conducted?

This trial has 20 study locations across Alabama, California, Colorado, Florida, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial