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NCT07001800 · ClinicalTrials.gov registry record · Phase 2
Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study
A Phase 2 study of Moderate Aortic Valve Stenosis, sponsored by Kardigan.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 1,276
- Enrollment target
- 20
- Study locations
NCT07001800: Recruiting Phase 2 study of Moderate Aortic Valve Stenosis, sponsored by Kardigan.
NCT07001800 is a Phase 2 study of Moderate Aortic Valve Stenosis that is actively recruiting participants, run by Kardigan. The registered enrollment target is 1,276 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (859% higher). The trial reports 20 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07001800, a Phase 2 study of Moderate Aortic Valve Stenosis, is actively recruiting participants, sponsored by Kardigan.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 1,276 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to evaluate if ataciguat slows the progression of moderate calcific aortic valve stenosis in adults.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Ataciguat
Study Locations (20)
Florida
- HCA Florida - JFK Hospital - Atlantis
- New Generation of Medical Research - Hialeah
- Memorial Healthcare System - Hollywood
- Jacksonville Center for Clinical Research - Jacksonville
- University of Miami - Miami
- New Generation of Medical Research - Naples - Naples
- Sarasota Memorial Hospital - Sarasota
- University of South Florida - Tampa
California
- National Heart Institute - Beverly Hills
- Hoag Memorial Hospital Presbyterian - Newport Beach
- Profound Research LLC at Southern California Heart Specialists - Pasadena
- University of California, San Francisco (UCSF) - Medical Center - San Francisco
- Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center - Torrance
Illinois
- Northwestern University The Feinberg School of Medicine - Chicago
- NorthShore University Health System - Glenview
- Midwest Cardiovascular Institute - Naperville
Alabama
- University of Alabama at Birmingham (UAB) - Medical Center - Birmingham
- Heart Center Research LLC - Huntsville
Arizona
- Onyx Clinical Research - Peoria - Peoria
Georgia
- Wellstar Kennestone Hospital - Marietta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,276 participants |
| Start Date | 2025-06-27 |
| Est. Completion | 2030-09-30 |
| Phase | Phase 2 |
What NCT07001800 shows while recruiting
NCT07001800 is an interventional study that assigns participants to a tested intervention. Its 1,276 participants enrollment target places it among the larger protocols in the corpus, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (859% higher).
The record links to 1 condition, with Moderate Aortic Valve Stenosis appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT07001800 names 20 study sites across 6 states, led by Florida, California, Illinois.
Frequently Asked Questions
What is clinical trial NCT07001800 about?
NCT07001800 is a clinical study titled "Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study". The purpose of this study is to evaluate if ataciguat slows the progression of moderate calcific aortic valve stenosis in adults.
What is the current status of trial NCT07001800?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 1,276 participants. The study started on 2025-06-27. Estimated completion is 2030-09-30.
What conditions does trial NCT07001800 study?
This clinical trial studies the following conditions: Moderate Aortic Valve Stenosis.
What interventions are being tested in trial NCT07001800?
The interventions under investigation include: Placebo (DRUG), Ataciguat (DRUG).
Who is sponsoring clinical trial NCT07001800?
This trial is sponsored by Kardigan, which has 4 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07001800 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Moderate Aortic Valve Stenosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07001800's enrollment target sits among peer trials
1,276 14th of 2000 higher than 1,987 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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