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NCT06999434 · ClinicalTrials.gov registry record · Phase 1
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
A Phase 1 study of SCI - Spinal Cord Injury and Alzheimer's Disease (AD), sponsored by Yale University.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 105
- Enrollment target
- 1
- Study location
NCT06999434: Recruiting Phase 1 study of SCI - Spinal Cord Injury and Alzheimer's Disease (AD), sponsored by Yale University.
NCT06999434 is a Phase 1 study of SCI - Spinal Cord Injury and Alzheimer's Disease (AD) that is actively recruiting participants, run by Yale University. The registered enrollment target is 105 participants, above the 30-participant average among 13 other SCI - Spinal Cord Injury trials with a reported enrollment target (250% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06999434, a Phase 1 study of SCI - Spinal Cord Injury and Alzheimer's Disease (AD), is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 105 participants
- Enrollment target
- 1
- Study location
Study Summary
The overall objective is to obtain an assessment of the pharmacokinetics of \[18F\]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Spinal Cord Injury (SCI) and Spinal radiculopathy (SR).
Primary Outcome
PET images measured with \[ 18F\]3F4AP will quantify demyelination, those obtained with \[18F\]MK6240 will quantify tau burden and those obtained with \[11C\]PiB will reflect amyloid burden. PET images acquired with \[18F\]3F4AP, \[18F\]MK6240 and \[11C\]PiB, will measure the tracers volume of distribution (VT).
Conditions Studied
Interventions
- DRUG [ 18F]3F4AP
- DRUG [18F]MK6240
- DRUG [11C]PIB
Study Locations (1)
Connecticut
- Yale University PET Center - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2025-05-05 |
| Est. Completion | 2030-05-05 |
| Phase | Phase 1 |
What NCT06999434 shows while recruiting
NCT06999434 is an interventional study that assigns participants to a tested intervention. The registered 105 participants enrollment target is mid-sized for trials with a published cap, above the 30-participant average among 13 other SCI - Spinal Cord Injury trials with a reported enrollment target (250% higher).
The record links to 6 conditions, with SCI - Spinal Cord Injury appearing as the primary indexed condition, and to 3 interventions - of which [ 18F]3F4AP is the first listed.
NCT06999434 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT06999434 about?
NCT06999434 is a clinical study titled "Exploring the Utility of [18F]3F4AP for Demyelination Imaging". The overall objective is to obtain an assessment of the pharmacokinetics of \[18F\]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Spinal Cord Injury (SCI) and Spinal radiculopathy (SR).
What is the current status of trial NCT06999434?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 105 participants. The study started on 2025-05-05. Estimated completion is 2030-05-05.
What conditions does trial NCT06999434 study?
This clinical trial studies the following conditions: SCI - Spinal Cord Injury, Alzheimer's Disease (AD), MCI, MS (Multiple Sclerosis), Demyelinating Disorders.
What interventions are being tested in trial NCT06999434?
The interventions under investigation include: [ 18F]3F4AP (DRUG), [18F]MK6240 (DRUG), [11C]PIB (DRUG).
Who is sponsoring clinical trial NCT06999434?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06999434 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06999434's enrollment target sits among peer trials
105 1st of 13 higher than 13 of 13 other SCI - Spinal Cord Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other SCI - Spinal Cord Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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