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A Study to Investigate the Safety and Efficacy of KQB168 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies
NCT06994806 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this clinical trial is to learn if KQB168 works to treat advanced solid tumor cancer in adults. It will also learn about the safety of KQB168. The main questions it aims to answer are: * What is the safe dose of KQB168 by itself or in combination with pembrolizumab? * Does KQB168 alone or in combination with pembrolizumab decrease the size of the tumor? * What happens to KQB168 in the body? Participants will: * Take KQB168 daily, alone or in combination with pembrolizumab * Visit the clinic about 8 times in the first 8 weeks, and then once every 3 weeks after that
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG KQB168
Study Locations (15)
Texas
- NEXT Austin — Austin
- Mary Crowley Cancer Research Centers — Dallas
- UT MD Anderson Cancer Center - Houston — Houston
- NEXT Huston — Houston
- NEXT Oncology — San Antonio
Florida
- Mayo Clinic - Jacksonville — Jacksonville
- Florida Cancer Specialists - Sarasota — Sarasota
Arizona
- Mayo Clinic - Phoenix — Phoenix
California
- USC Norris Comprehensive Cancer Center — Los Angeles
Colorado
- Sarah Cannon Cancer Institute at HealthONE — Denver
Connecticut
- Yale Cancer Center- New Haven — New Haven
Iowa
- University of Iowa — Iowa City
Minnesota
- Mayo Clinic - Rochester — Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 84 participants |
| Start Date | 2025-06-24 |
| Est. Completion | 2028-05-31 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06994806
The ClinicalTrials.gov registry entry for NCT06994806 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 84 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Kumquat Biosciences, which has 32 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Solid Tumor Malignancies appearing as the primary indexed condition, and to 2 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06994806 reports 15 study locations spanning 10 distinct geographic areas — top geographies include Texas, Florida, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06994806 about?
NCT06994806 is a clinical study titled "A Study to Investigate the Safety and Efficacy of KQB168 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies". The goal of this clinical trial is to learn if KQB168 works to treat advanced solid tumor cancer in adults. It will also learn about the safety of KQB168. The main questions it aims to answer are: * What is the safe dose of KQB168 by itself or in combination with pembrolizumab? * Does KQB168 alone ...
What is the current status of trial NCT06994806?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 84 participants. The study started on 2025-06-24. Estimated completion is 2028-05-31.
What conditions does trial NCT06994806 study?
This clinical trial studies the following conditions: Solid Tumor Malignancies. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06994806?
The interventions under investigation include: Pembrolizumab (DRUG), KQB168 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06994806?
This trial is sponsored by Kumquat Biosciences, which has 32 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06994806 being conducted?
This trial has 15 study locations across Arizona, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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