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NCT02391519 · ClinicalTrials.gov registry record
Effects of High Altitude on AMPK Activation
A clinical trial of Pregnancy and Preeclampsia, sponsored by University of Colorado, Denver.
- Recruiting
- Registry status
- 84
- Enrollment target
- 1
- Study location
NCT02391519: Recruiting study of Pregnancy and Preeclampsia, sponsored by University of Colorado, Denver.
NCT02391519 is a study of Pregnancy and Preeclampsia that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 84 participants, below the 872-participant average among 191 other Pregnancy trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02391519, a study of Pregnancy and Preeclampsia, is actively recruiting participants, sponsored by University of Colorado, Denver.
- RECRUITING
- Registry status
- 84 participants
- Enrollment target
- 1
- Study location
Study Summary
Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA). If altered MA vasoreactivity is found, further studies may be able to link these changes to the increased rates of PreE and IUGR at altitude and contribute to the understanding of these two disorders.
Primary Outcome
Myometrial artery dimensions as quantified by immunohistochemistry or other staining techniques, and results of studies of isolated myometrial artery studies in which vasoconstrictor and vasodilator responses to pharmacological agonists are measured using absolute values and the percent maximal contraction to potassium chloride.
Conditions Studied
Interventions
- PROCEDURE Collection of myometrial, cord blood, and placental tissue samples
Study Locations (1)
Colorado
- University of Colorado Denver Anschutz Medical Campus - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 84 participants |
| Start Date | 2016-01 |
| Est. Completion | 2026-12-31 |
What NCT02391519 shows while recruiting
NCT02391519 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 84 participants, a relatively small participant target, below the 872-participant average among 191 other Pregnancy trials with a reported enrollment target (90% lower).
The record links to 3 conditions, with Pregnancy appearing as the primary indexed condition, and to 1 intervention - of which Collection of myometrial, cord blood, and placental tissue samples is the first listed.
NCT02391519 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT02391519 about?
NCT02391519 is a clinical study titled "Effects of High Altitude on AMPK Activation". Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue ...
What is the current status of trial NCT02391519?
This trial is currently recruiting. The enrollment target is 84 participants. The study started on 2016-01. Estimated completion is 2026-12-31.
What conditions does trial NCT02391519 study?
This clinical trial studies the following conditions: Pregnancy, Preeclampsia, IUGR.
What interventions are being tested in trial NCT02391519?
The interventions under investigation include: Collection of myometrial, cord blood, and placental tissue samples (PROCEDURE).
Who is sponsoring clinical trial NCT02391519?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02391519 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pregnancy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02391519's enrollment target sits among peer trials
84 126th of 191 higher than 65 of 191 other Pregnancy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pregnancy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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