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RECRUITING Phase 1

A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

NCT06720987 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this clinical trial is to learn if KQB365 works to treat advanced solid tumor cancer in adults. It will also learn about the safety of KQB365. The main questions it aims to answer are: * What is the safe dose of KQB365 by itself or in combination with cetuximab? * Does KQB365 alone or in combination with cetuximab decrease the size of the tumor? * What happens to KQB365 in the body? Participants will: * Receive KQB365 infusion weekly alone or in combination with cetuximab * Visit the clinic about 9 times in the first 6 weeks, and then once every week after that.

Interventions

  • DRUG Cetuximab
  • DRUG KQB365

Study Locations (9)

Arizona

  • Mayo Clinic, Phoenix — Phoenix

Colorado

  • Sarah Cannon Cancer Institute at HealthONE — Denver

Florida

  • Mayo Clinic, Jacksonville — Jacksonville

Massachusetts

  • Dana Farber Cancer Institute — Boston

Michigan

  • START Midwest — Grand Rapids

Minnesota

  • Mayo Clinic, Rochester — Rochester

Ohio

  • Cleveland Clinic, Taussig Cancer Institute — Cleveland

Texas

  • NEXT Oncology — San Antonio

Trial Details

FieldValue
Enrollment Target 128 participants
Start Date 2025-02-04
Est. Completion 2030-06-30
Phase Phase 1

Sponsor

Kumquat Biosciences

32 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06720987

The ClinicalTrials.gov registry entry for NCT06720987 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 128 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Kumquat Biosciences, which has 32 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Solid Tumor Malignancies appearing as the primary indexed condition, and to 2 interventions — of which Cetuximab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06720987 reports 9 study locations spanning 9 distinct geographic areas — top geographies include Arizona, Colorado, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06720987 about?

NCT06720987 is a clinical study titled "A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies". The goal of this clinical trial is to learn if KQB365 works to treat advanced solid tumor cancer in adults. It will also learn about the safety of KQB365. The main questions it aims to answer are: * What is the safe dose of KQB365 by itself or in combination with cetuximab? * Does KQB365 alone or i...

What is the current status of trial NCT06720987?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 128 participants. The study started on 2025-02-04. Estimated completion is 2030-06-30.

What conditions does trial NCT06720987 study?

This clinical trial studies the following conditions: Solid Tumor Malignancies, CRC (Colorectal Cancer), KRAS G12C Mutation, KRAS G12S Mutation. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06720987?

The interventions under investigation include: Cetuximab (DRUG), KQB365 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06720987?

This trial is sponsored by Kumquat Biosciences, which has 32 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06720987 being conducted?

This trial has 9 study locations across Arizona, Colorado, Florida, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial