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NCT06969326 · ClinicalTrials.gov registry record · Phase 3
Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy
A Phase 3 study of Gender Dysphoria and Hysterectomy, sponsored by Women and Infants Hospital of Rhode Island.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 48
- Enrollment target
- 1
- Study location
NCT06969326 is a Phase 3 study of Gender Dysphoria and Hysterectomy that is actively recruiting participants, run by Women and Infants Hospital of Rhode Island. The registered enrollment target is 48 participants, below the 173-participant average among 8 other Gender Dysphoria trials with a reported enrollment target (72% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06969326, a Phase 3 study of Gender Dysphoria and Hysterectomy, is actively recruiting participants, sponsored by Women and Infants Hospital of Rhode Island.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to determine if applying a single dose of topical estrogen cream in the operating room at the end of your hysterectomy (removal of uterus and cervix) improves the postoperative experience with bleeding and potential symptoms of dysphoria (a feeling of discomfort or distress). Topical estrogen cream is sometimes used if patients have increased risk of bleeding with surgery but is not currently utilized in a consistent way. This study aims to answer the question of whether this is a helpful treatment and should be included in standard postoperative care.
Conditions Studied
Interventions
- OTHER No intervention
- DRUG Use of topical estradiol
Study Locations (1)
Rhode Island
- Women & Infants Hospital - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2025-05-01 |
| Est. Completion | 2026-12-01 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06969326
The ClinicalTrials.gov registry entry for NCT06969326 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 48 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 173-participant average among 8 other Gender Dysphoria trials with a reported enrollment target (72% lower). The listed sponsor is Women and Infants Hospital of Rhode Island, which has 65 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Gender Dysphoria appearing as the primary indexed condition, and to 2 interventions - of which No intervention is the first listed.
NCT06969326 reports 1 study location spanning 1 distinct geographic area - top geographies include Rhode Island.
Frequently Asked Questions
What is clinical trial NCT06969326 about?
NCT06969326 is a clinical study titled "Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy". The purpose of this study is to determine if applying a single dose of topical estrogen cream in the operating room at the end of your hysterectomy (removal of uterus and cervix) improves the postoperative experience with bleeding and potential symptoms of dysphoria (a feeling of discomfort or distr...
What is the current status of trial NCT06969326?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 48 participants. The study started on 2025-05-01. Estimated completion is 2026-12-01.
What conditions does trial NCT06969326 study?
This clinical trial studies the following conditions: Gender Dysphoria, Hysterectomy, Postoperative Bleeding.
What interventions are being tested in trial NCT06969326?
The interventions under investigation include: No intervention (OTHER), Use of topical estradiol (DRUG).
Who is sponsoring clinical trial NCT06969326?
This trial is sponsored by Women and Infants Hospital of Rhode Island, which has 65 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06969326 being conducted?
This trial has 1 study location across Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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