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NCT06950177 · ClinicalTrials.gov registry record · Phase 1
Pancoronavirus Vaccine Study in Healthy Adults
A Phase 1 study of SARS CoV 2 Infection and COVID-19 Respiratory Infection, sponsored by Duke University.
- Active
- Registry status
- Phase 1
- Development phase
- 51
- Enrollment target
- 1
- Study location
NCT06950177 is a Phase 1 study of SARS CoV 2 Infection and COVID-19 Respiratory Infection that is active but no longer recruiting, run by Duke University. The registered enrollment target is 51 participants, below the 4,963-participant average among 28 other SARS CoV 2 Infection trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06950177, a Phase 1 study of SARS CoV 2 Infection and COVID-19 Respiratory Infection, is active but no longer recruiting, sponsored by Duke University.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 51 participants
- Enrollment target
- 1
- Study location
Study Summary
Coronaviruses (CoVs) have caused the severe acute respiratory syndrome (SARS) outbreak, the Middle East Respiratory Syndrome (MERS) outbreak, and now the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Although there are several approved or authorized vaccines for SARS-CoV-2, there are currently no vaccines approved to prevent diseases caused by multiple different coronaviruses. Two countermeasures with promise for controlling coronavirus outbreaks are recombinant neutralizing antibodies and vaccines directed against the virus. Between these two countermeasures, the ultimate solution to control the current COVID-19 pandemic and future CoV outbreaks is a pancoronavirus vaccine. In particular, a vaccine that can induce broader protection and can prevent severe disease caused by current SARS-CoV-2 variants of concern would help mitigate significant morbidity and mortality following SARS-CoV-2 infection. Additionally, an optimal pancoronavirus vaccine would prevent severe disease from other SARS-related viruses in the genus of coronaviruses-betacoronavirus-that are responsible for past outbreaks or could cause the next major outbreak in humans. Such a broadly active coronavirus vaccine would be an impactful first step towards preventing all life-threatening coronavirus human disease. The proposed vaccine immunogen (Cov-RBD-scNP-001) is composed of an engineered receptor binding domain (RBD) of SARS-CoV-2 WA-1 covalently linked in vitro to the surface of a Helicobacter pylori ferritin protein nanoparticle (RBD-scNP). The RBD has been engineered at two sites to improve its expression. The protein nanoparticle is composed of 24 individual ferritin subunits each of which can have a SARS-CoV-2 WA-1 RBD attached to it via a nine amino acid linker. The protein nanoparticle will be delivered with 3M-052-AF adjuvant - a TLR 7/8 agonist.
Conditions Studied
Interventions
- BIOLOGICAL CoV-RBD-scNP-001 and 3M-052-AF
Study Locations (1)
North Carolina
- Duke University Health System - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 51 participants |
| Start Date | 2025-07-08 |
| Est. Completion | 2026-08-30 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06950177
The ClinicalTrials.gov registry entry for NCT06950177 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 51 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 4,963-participant average among 28 other SARS CoV 2 Infection trials with a reported enrollment target (99% lower). The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with SARS CoV 2 Infection appearing as the primary indexed condition, and to 1 intervention - of which CoV-RBD-scNP-001 and 3M-052-AF is the first listed.
NCT06950177 reports 1 study location spanning 1 distinct geographic area - top geographies include North Carolina.
Frequently Asked Questions
What is clinical trial NCT06950177 about?
NCT06950177 is a clinical study titled "Pancoronavirus Vaccine Study in Healthy Adults". Coronaviruses (CoVs) have caused the severe acute respiratory syndrome (SARS) outbreak, the Middle East Respiratory Syndrome (MERS) outbreak, and now the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Although there are several approved or authorized vaccines for SARS-CoV-2, ...
What is the current status of trial NCT06950177?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 51 participants. The study started on 2025-07-08. Estimated completion is 2026-08-30.
What conditions does trial NCT06950177 study?
This clinical trial studies the following conditions: SARS CoV 2 Infection, COVID-19 Respiratory Infection, COVID-19 Vaccine.
What interventions are being tested in trial NCT06950177?
The interventions under investigation include: CoV-RBD-scNP-001 and 3M-052-AF (BIOLOGICAL).
Who is sponsoring clinical trial NCT06950177?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06950177 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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