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NCT06926660 · ClinicalTrials.gov registry record · Phase 2

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Chronic Kidney Disease

A Phase 2 study of Chronic Kidney Disease, sponsored by Boehringer Ingelheim.

Recruiting
Registry status
Phase 2
Development phase
416
Enrollment target
20
Study locations

NCT06926660 is a Phase 2 study of Chronic Kidney Disease that is actively recruiting participants, run by Boehringer Ingelheim. The registered enrollment target is 416 participants, below the 3,203-participant average among 101 other Chronic Kidney Disease trials with a reported enrollment target (87% lower). The trial reports 20 study locations across 8 states.

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The verdict

NCT06926660, a Phase 2 study of Chronic Kidney Disease, is actively recruiting participants, sponsored by Boehringer Ingelheim.

RECRUITING
Registry status
Phase 2
Development phase
416 participants
Enrollment target
20
Study locations

Study Summary

This study is open to adults with chronic kidney disease (CKD) that is at risk of getting worse. People who have taken a specific type of medication for kidney disease called SGLT2 inhibitor within 1 month before the study or have certain health conditions cannot take part in this study. The purpose of this study is to find out whether a medicine called vicadrostat, used in combination with another medicine called empagliflozin, works in people with chronic kidney disease. In this study, participants are randomly assigned to one of two groups. Participants have an equal chance of being assigned to either group. In one group, participants take the 2 study medicines, vicadrostat and empagliflozin, every day for 3 months. In the other group, participants take placebo and empagliflozin for the first 1.5 months, and then they take vicadrostat and empagliflozin together for the next 1.5 months. The study medicines are taken orally as tablets. Placebo tablets look like vicadrostat tablets but do not contain any medicine. Participants are in the study for about 4.5 months. During this time, they visit the study site multiple times. Doctors regularly test kidney function by measuring specific proteins in the blood and urine. The results are compared between the two groups to see whether there are differences between starting the study medicines at the same time or one after the other. The doctors also regularly check participants' health and take note of any unwanted effects.

Conditions Studied

Chronic Kidney Disease

Interventions

  • DRUG Empagliflozin
  • DRUG Vicadrostat
  • DRUG Placebo matching vicadrostat

Study Locations (20)

Florida

  • Clinical Research of Brandon LLC - Brandon
  • Hillcrest Medical Research - DeLand
  • Encore Medical Research - Hollywood
  • Finlay Medical Research Corp - Miami
  • Total Research Group, LLC - Miami
  • San Marcus Research Clinic, Inc. - Miami Lakes
  • West Orange Endocrinology - Ocoee
  • Florida Kidney Physicians - Riverview/Brandon - Riverview

California

  • Orange County Clinical Trials - Anaheim
  • North America Research Institute - San Dimas
  • Valiance Clinical Research-Tarzana-68237 - Tarzana
  • Amicis Research Center - Valencia - Valencia
  • Focus Clinical Research - West Hills

Illinois

  • Research by Design, LLC - Chicago
  • Nephrology Associates of Northern Illinois and Indiana - Oak Brook - Hinsdale

Alabama

  • Apogee Clinical Research - Huntsville

Georgia

  • Masters of Clinical Research, Inc - Augusta

Idaho

  • Boise Kidney and Hypertension, PLLC - Boise

Indiana

  • Nephrology Associates of Northern Illinois and Indiana - Fort Wayne - Fort Wayne

Kansas

  • Kansas Nephrology Research Institute, LLC - Wichita

Trial Details

FieldValue
Enrollment Target 416 participants
Start Date 2025-07-18
Est. Completion 2026-08-20
Phase Phase 2

Sponsor

Boehringer Ingelheim

515 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06926660

The ClinicalTrials.gov registry entry for NCT06926660 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 416 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 3,203-participant average among 101 other Chronic Kidney Disease trials with a reported enrollment target (87% lower). The listed sponsor is Boehringer Ingelheim, which has 515 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Chronic Kidney Disease appearing as the primary indexed condition, and to 3 interventions - of which Empagliflozin is the first listed.

NCT06926660 reports 20 study locations spanning 8 distinct geographic areas - top geographies include Florida, California, Illinois.

Frequently Asked Questions

What is clinical trial NCT06926660 about?

NCT06926660 is a clinical study titled "A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Chronic Kidney Disease". This study is open to adults with chronic kidney disease (CKD) that is at risk of getting worse. People who have taken a specific type of medication for kidney disease called SGLT2 inhibitor within 1 month before the study or have certain health conditions cannot take part in this study. The purpose...

What is the current status of trial NCT06926660?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 416 participants. The study started on 2025-07-18. Estimated completion is 2026-08-20.

What conditions does trial NCT06926660 study?

This clinical trial studies the following conditions: Chronic Kidney Disease.

What interventions are being tested in trial NCT06926660?

The interventions under investigation include: Empagliflozin (DRUG), Vicadrostat (DRUG), Placebo matching vicadrostat (DRUG).

Who is sponsoring clinical trial NCT06926660?

This trial is sponsored by Boehringer Ingelheim, which has 515 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06926660 being conducted?

This trial has 20 study locations across Alabama, California, Florida, Georgia, Idaho. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.