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NCT06909110 · ClinicalTrials.gov registry record · Phase 1
Viral Specific T-Lymphocytes to Treat Infection With Adenovirus, Cytomegalovirus or Epstein-Barr Virus in Patients With Compromised Immunity
A Phase 1 study of Cytomegalovirus Infections and Adenovirus, sponsored by Jessie L. Alexander.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 25
- Enrollment target
- 3
- Study locations
NCT06909110: Recruiting Phase 1 study of Cytomegalovirus Infections and Adenovirus, sponsored by Jessie L. Alexander.
NCT06909110 is a Phase 1 study of Cytomegalovirus Infections and Adenovirus that is actively recruiting participants, run by Jessie L. Alexander. The registered enrollment target is 25 participants, below the 202-participant average among 24 other Cytomegalovirus Infections trials with a reported enrollment target (88% lower). The trial reports 3 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06909110, a Phase 1 study of Cytomegalovirus Infections and Adenovirus, is actively recruiting participants, sponsored by Jessie L. Alexander.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 25 participants
- Enrollment target
- 3
- Study locations
Study Summary
The primary purpose of this phase I/II study is to evaluate whether partially matched, ≥2/6 HLA-matched, viral specific T cells have efficacy against adenovirus, CMV, and EBV, in subjects who have previously received any type of allogeneic HCT or solid organ transplant (SOT), or have compromised immunity. Reconstitution of anti-viral immunity by donor-derived cytotoxic T lymphocytes has shown promise in preventing and treating infections with adenovirus, CMV, and EBV. However, the weeks taken to prepare patient-specific products, and cost associated with products that may not be used limits their value. In this trial, we will evaluate viral specific T cells generated by gamma capture technology. Eligible patients will include HCT and/or SOT recipients, and/or patients with compromised immunity who have adenovirus, CMV, or EBV infection or refractory viremia that is persistent despite standard therapy. Infusion of the cellular product will be assessed for safety and efficacy.
Primary Outcome
The number of patients who develop Grade III-IV acute graft versus host disease (GVHD) attributed to the viral specific T cells.
Conditions Studied
Interventions
- BIOLOGICAL Adenovirus Specific T- Lymphocytes
- BIOLOGICAL Cytomegalovirus Specific T-Lymphocytes
- BIOLOGICAL Epstein-Barr Virus Specific T-Lymphocytes
Study Locations (3)
California
- Jessie Alexander - Palo Alto
- Lucile Packard Children's Hospital - Palo Alto
- Lucile Packard Children's Hospital - Palo Alto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2025-04-30 |
| Est. Completion | 2032-01-01 |
| Phase | Phase 1 |
What NCT06909110 shows while recruiting
NCT06909110 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 202-participant average among 24 other Cytomegalovirus Infections trials with a reported enrollment target (88% lower).
The record links to 3 conditions, with Cytomegalovirus Infections appearing as the primary indexed condition, and to 3 interventions - of which Adenovirus Specific T- Lymphocytes is the first listed.
NCT06909110 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06909110 about?
NCT06909110 is a clinical study titled "Viral Specific T-Lymphocytes to Treat Infection With Adenovirus, Cytomegalovirus or Epstein-Barr Virus in Patients With Compromised Immunity". The primary purpose of this phase I/II study is to evaluate whether partially matched, ≥2/6 HLA-matched, viral specific T cells have efficacy against adenovirus, CMV, and EBV, in subjects who have previously received any type of allogeneic HCT or solid organ transplant (SOT), or have compromised imm...
What is the current status of trial NCT06909110?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 25 participants. The study started on 2025-04-30. Estimated completion is 2032-01-01.
What conditions does trial NCT06909110 study?
This clinical trial studies the following conditions: Cytomegalovirus Infections, Adenovirus, Epstein-Barr Virus Infections.
What interventions are being tested in trial NCT06909110?
The interventions under investigation include: Adenovirus Specific T- Lymphocytes (BIOLOGICAL), Cytomegalovirus Specific T-Lymphocytes (BIOLOGICAL), Epstein-Barr Virus Specific T-Lymphocytes (BIOLOGICAL).
Who is sponsoring clinical trial NCT06909110?
This trial is sponsored by Jessie L. Alexander, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06909110 being conducted?
This trial has 3 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06909110's enrollment target sits among peer trials
25 18th of 24 higher than 5 of 24 other Cytomegalovirus Infections trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cytomegalovirus Infections trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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