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NCT06868589 · ClinicalTrials.gov registry record · Phase 4
Reducing Pain With Methadone and Ketamine in Liver Transplant
A Phase 4 study of Liver Transplantation, sponsored by Lahey Clinic.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 50
- Enrollment target
- 2
- Study locations
NCT06868589: Recruiting Phase 4 study of Liver Transplantation, sponsored by Lahey Clinic.
NCT06868589 is a Phase 4 study of Liver Transplantation that is actively recruiting participants, run by Lahey Clinic. The registered enrollment target is 50 participants, below the 319-participant average among 12 other Liver Transplantation trials with a reported enrollment target (84% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06868589, a Phase 4 study of Liver Transplantation, is actively recruiting participants, sponsored by Lahey Clinic.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 50 participants
- Enrollment target
- 2
- Study locations
Study Summary
The goal of this clinical trial is to learn if using methadone and ketamine during an adult deceased donor liver transplant can help decrease pain after surgery. The main questions it aims to answer are: * What impact does using methadone and ketamine during a deceased donor liver transplant have on pain after surgery? * Does the use of methadone and ketamine also have an impact on mental confusion (delirium) after surgery? Researchers will compare the use of methadone and ketamine to standard of care to see if the two drugs work to decrease pain and impact delirium after liver transplant. Participants will: * Receive either methadone and ketamine or standard of care during their deceased donor liver transplant. * Allow researchers to follow medical care throughout inpatient stay.
Primary Outcome
postoperative opioid consumption (measured as morphine milligram equivalents ((MME)) 48 hours after surgery
Conditions Studied
Interventions
- DRUG Methadone
- DRUG fentanyl
- DRUG Hydromorphone
- DRUG ketamine
Study Locations (2)
Massachusetts
- Lahey Hospital and Medical Center - Burlington
- Lahey Hospital and Medical Center - Burlington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-06-30 |
| Est. Completion | 2026-09-01 |
| Phase | Phase 4 |
What NCT06868589 shows while recruiting
NCT06868589 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 319-participant average among 12 other Liver Transplantation trials with a reported enrollment target (84% lower).
The record links to 1 condition, with Liver Transplantation appearing as the primary indexed condition, and to 4 interventions - of which Methadone is the first listed.
NCT06868589 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06868589 about?
NCT06868589 is a clinical study titled "Reducing Pain With Methadone and Ketamine in Liver Transplant". The goal of this clinical trial is to learn if using methadone and ketamine during an adult deceased donor liver transplant can help decrease pain after surgery. The main questions it aims to answer are: * What impact does using methadone and ketamine during a deceased donor liver transplant have ...
What is the current status of trial NCT06868589?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 50 participants. The study started on 2025-06-30. Estimated completion is 2026-09-01.
What conditions does trial NCT06868589 study?
This clinical trial studies the following conditions: Liver Transplantation.
What interventions are being tested in trial NCT06868589?
The interventions under investigation include: Methadone (DRUG), fentanyl (DRUG), Hydromorphone (DRUG), ketamine (DRUG).
Who is sponsoring clinical trial NCT06868589?
This trial is sponsored by Lahey Clinic, which has 43 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06868589 being conducted?
This trial has 2 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Liver Transplantation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06868589's enrollment target sits among peer trials
50 10th of 12 higher than 3 of 12 other Liver Transplantation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Liver Transplantation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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