Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04023773 · ClinicalTrials.gov registry record · NA
Sequential Hypo- and Normo-thermic Perfusion to Preserve Extended Criteria Donor Livers for Transplantation
A NA study of Liver Transplantation, sponsored by Koji Hashimoto.
- Active
- Registry status
- NA
- Development phase
- 18
- Enrollment target
- 1
- Study location
NCT04023773: Active NA study of Liver Transplantation, sponsored by Koji Hashimoto.
NCT04023773 is a NA study of Liver Transplantation that is active but no longer recruiting, run by Koji Hashimoto. The registered enrollment target is 18 participants, below the 322-participant average among 12 other Liver Transplantation trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04023773, a NA study of Liver Transplantation, is active but no longer recruiting, sponsored by Koji Hashimoto.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 18 participants
- Enrollment target
- 1
- Study location
Study Summary
Hypothermic machine perfusion (HMP) has been shown to be beneficial to preserve extended criteria donor (ECD) livers for transplantation. Normothermic machine perfusion (NMP) had the same benefits and also the convenience on liver quality assessment. The investigators proposed to do sequential HMP (1-4 hours) and NMP (1-14 hours) on 18 ECD transplanted human livers by using an institutional-developed perfusion device for liver transplantation.
Primary Outcome
Patient survival will be recorded at 1 month post transplantation.
Conditions Studied
Interventions
- DEVICE Liver Machine Perfusion (MP) device
Study Locations (1)
Ohio
- Cleveland Clinic - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2021-05-01 |
| Est. Completion | 2027-01-30 |
| Phase | NA |
What the registry record for NCT04023773 still lists
NCT04023773 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 322-participant average among 12 other Liver Transplantation trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Liver Transplantation appearing as the primary indexed condition, and to 1 intervention - of which Liver Machine Perfusion (MP) device is the first listed.
NCT04023773 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT04023773 about?
NCT04023773 is a clinical study titled "Sequential Hypo- and Normo-thermic Perfusion to Preserve Extended Criteria Donor Livers for Transplantation". Hypothermic machine perfusion (HMP) has been shown to be beneficial to preserve extended criteria donor (ECD) livers for transplantation. Normothermic machine perfusion (NMP) had the same benefits and also the convenience on liver quality assessment. The investigators proposed to do sequential HMP (...
What is the current status of trial NCT04023773?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 18 participants. The study started on 2021-05-01. Estimated completion is 2027-01-30.
What conditions does trial NCT04023773 study?
This clinical trial studies the following conditions: Liver Transplantation.
What interventions are being tested in trial NCT04023773?
The interventions under investigation include: Liver Machine Perfusion (MP) device (DEVICE).
Who is sponsoring clinical trial NCT04023773?
This trial is sponsored by Koji Hashimoto, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04023773 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Liver Transplantation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04023773's enrollment target sits among peer trials
18 12th of 12 higher than 1 of 12 other Liver Transplantation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Liver Transplantation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Mediterranean Diet Post-liver Transplantation
RECRUITING · NA
-
Continued Access Study to Evaluate Performance of the Organ Recovery Systems _LifePort® Liver Transporter System, a Machine Perfusion System, for Liver Transplant (PILOT™_CA)
ACTIVE NOT RECRUITING · NA
-
Study of Resistance Strengthening Versus Ambulation Post-Liver Transplant
COMPLETED · NA
-
HOPE Against Cancer Recurrence in HCC
RECRUITING · Phase 4
-
Reducing Pain With Methadone and Ketamine in Liver Transplant
RECRUITING · Phase 4
-
Immune Tolerance Induction After Liver Transplantation
RECRUITING · Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01245179 · 18 participants · Phase 1
Study of Panobinostat (LBH589) in Patients With Sickle Cell Disease
- NCT01999361 · 18 participants · NA
Prevention of de Novo Allosensitization in Islet Transplant Recipients Following Complete Graft Loss
- NCT02359825 · 18 participants · Phase 1
Nerve Repair Using Hydrophilic Polymers to Promote Immediate Fusion of Severed Axons and Swift Return of Function
- NCT02870244 · 18 participants · Phase 1
Adoptive T Cell Immunotherapy for Advanced Melanoma Using Engineered Lymphocytes
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI