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NCT04793360 · ClinicalTrials.gov registry record
Molecular Assessment and Profiling of Liver Transplant Recipients
A clinical trial of Liver Transplantation and Biomarkers, sponsored by CareDx.
- Active
- Registry status
- 1,500
- Enrollment target
- 20
- Study locations
NCT04793360: Active study of Liver Transplantation and Biomarkers, sponsored by CareDx.
NCT04793360 is a study of Liver Transplantation and Biomarkers that is active but no longer recruiting, run by CareDx. The registered enrollment target is 1,500 participants, above the 198-participant average among 12 other Liver Transplantation trials with a reported enrollment target (658% higher). The trial reports 20 study locations across 16 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04793360, a study of Liver Transplantation and Biomarkers, is active but no longer recruiting, sponsored by CareDx.
- ACTIVE NOT RECRUITING
- Registry status
- 1,500 participants
- Enrollment target
- 20
- Study locations
Study Summary
The objective of this protocol is to conduct longitudinal and prospective studies of liver transplant recipients, using a multimodality approach, akin to that used in kidney transplantation. The primary aim will compare the clinical outcomes of LiverCare post-transplant surveillance in liver transplant with standard of care consisting of liver function tests, DSA measurements, drug level monitoring, and 'for cause' biopsy. The protocol will assess the correlation between clinical events (e.g. rejection, recurrent disease, biliary obstruction), dd-cfDNA levels, gene expression profiling, ability to assess microchimerism, develop predictive analytics, infectious disease diagnoses and finally examine graft histology.
Primary Outcome
LiverCare will be measured 7 times in year 1 and quarterly each year. A total of 15 surveillance points per subject in addition to for-cause testing based on clinical changes. Liver care will be collected at the time of all histologic analyses whether 'for cause' or 'surveillance'
Conditions Studied
Interventions
- DEVICE LiverCare
Study Locations (20)
Massachusetts
- Massachusetts General Hospital - Boston
- Beth Israel Deaconess Medical Center (BIDMC) - Boston
Michigan
- University of Michigan - Ann Arbor
- Henry Ford Health System - Detroit
New York
- Icahn School of Medicine at Mount Sinai - New York
- Westchester Medical Center - Valhalla
North Carolina
- Atrium Health - Charlotte
- Duke University - Durham
California
- Keck Medical Center of USC - Los Angeles
District of Columbia
- MedStar Georgetown University Hospital - Washington D.C.
Florida
- Tampa General Hospital - Tampa
Georgia
- Piedmont Healthcare - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,500 participants |
| Start Date | 2021-05-26 |
| Est. Completion | 2028-03-31 |
What the registry record for NCT04793360 still lists
NCT04793360 is an observational study that tracks outcomes without assigning an intervention. Its 1,500 participants enrollment target places it among the larger protocols in the corpus, above the 198-participant average among 12 other Liver Transplantation trials with a reported enrollment target (658% higher).
The record links to 2 conditions, with Liver Transplantation appearing as the primary indexed condition, and to 1 intervention - of which LiverCare is the first listed.
NCT04793360 names 20 study sites across 16 states, led by Massachusetts, Michigan, New York.
Frequently Asked Questions
What is clinical trial NCT04793360 about?
NCT04793360 is a clinical study titled "Molecular Assessment and Profiling of Liver Transplant Recipients". The objective of this protocol is to conduct longitudinal and prospective studies of liver transplant recipients, using a multimodality approach, akin to that used in kidney transplantation. The primary aim will compare the clinical outcomes of LiverCare post-transplant surveillance in liver transpl...
What is the current status of trial NCT04793360?
This trial is currently active not recruiting. The enrollment target is 1,500 participants. The study started on 2021-05-26. Estimated completion is 2028-03-31.
What conditions does trial NCT04793360 study?
This clinical trial studies the following conditions: Liver Transplantation, Biomarkers.
What interventions are being tested in trial NCT04793360?
The interventions under investigation include: LiverCare (DEVICE).
Who is sponsoring clinical trial NCT04793360?
This trial is sponsored by CareDx, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04793360 being conducted?
This trial has 20 study locations across California, District of Columbia, Florida, Georgia, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Liver Transplantation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04793360's enrollment target sits among peer trials
1,500 1st of 12 higher than 12 of 12 other Liver Transplantation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Liver Transplantation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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