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NCT04793360 · ClinicalTrials.gov registry record
Molecular Assessment and Profiling of Liver Transplant Recipients
A clinical trial of Liver Transplantation and Biomarkers, sponsored by CareDx.
- Active
- Registry status
- 1,500
- Enrollment target
- 20
- Study locations
NCT04793360 is a study of Liver Transplantation and Biomarkers that is active but no longer recruiting, run by CareDx. The registered enrollment target is 1,500 participants, above the 198-participant average among 12 other Liver Transplantation trials with a reported enrollment target (658% higher). The trial reports 20 study locations across 16 states.
The verdict
NCT04793360, a study of Liver Transplantation and Biomarkers, is active but no longer recruiting, sponsored by CareDx.
- ACTIVE NOT RECRUITING
- Registry status
- 1,500 participants
- Enrollment target
- 20
- Study locations
Study Summary
The objective of this protocol is to conduct longitudinal and prospective studies of liver transplant recipients, using a multimodality approach, akin to that used in kidney transplantation. The primary aim will compare the clinical outcomes of LiverCare post-transplant surveillance in liver transplant with standard of care consisting of liver function tests, DSA measurements, drug level monitoring, and 'for cause' biopsy. The protocol will assess the correlation between clinical events (e.g. rejection, recurrent disease, biliary obstruction), dd-cfDNA levels, gene expression profiling, ability to assess microchimerism, develop predictive analytics, infectious disease diagnoses and finally examine graft histology.
Conditions Studied
Interventions
- DEVICE LiverCare
Study Locations (20)
Massachusetts
- Massachusetts General Hospital - Boston
- Beth Israel Deaconess Medical Center (BIDMC) - Boston
Michigan
- University of Michigan - Ann Arbor
- Henry Ford Health System - Detroit
New York
- Icahn School of Medicine at Mount Sinai - New York
- Westchester Medical Center - Valhalla
North Carolina
- Atrium Health - Charlotte
- Duke University - Durham
California
- Keck Medical Center of USC - Los Angeles
District of Columbia
- MedStar Georgetown University Hospital - Washington D.C.
Florida
- Tampa General Hospital - Tampa
Georgia
- Piedmont Healthcare - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,500 participants |
| Start Date | 2021-05-26 |
| Est. Completion | 2028-03-31 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04793360
The ClinicalTrials.gov registry entry for NCT04793360 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 1,500 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 198-participant average among 12 other Liver Transplantation trials with a reported enrollment target (658% higher). The listed sponsor is CareDx, which has 8 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Liver Transplantation appearing as the primary indexed condition, and to 1 intervention - of which LiverCare is the first listed.
NCT04793360 reports 20 study locations spanning 16 distinct geographic areas - top geographies include Massachusetts, Michigan, New York.
Frequently Asked Questions
What is clinical trial NCT04793360 about?
NCT04793360 is a clinical study titled "Molecular Assessment and Profiling of Liver Transplant Recipients". The objective of this protocol is to conduct longitudinal and prospective studies of liver transplant recipients, using a multimodality approach, akin to that used in kidney transplantation. The primary aim will compare the clinical outcomes of LiverCare post-transplant surveillance in liver transpl...
What is the current status of trial NCT04793360?
This trial is currently active not recruiting. The enrollment target is 1,500 participants. The study started on 2021-05-26. Estimated completion is 2028-03-31.
What conditions does trial NCT04793360 study?
This clinical trial studies the following conditions: Liver Transplantation, Biomarkers.
What interventions are being tested in trial NCT04793360?
The interventions under investigation include: LiverCare (DEVICE).
Who is sponsoring clinical trial NCT04793360?
This trial is sponsored by CareDx, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04793360 being conducted?
This trial has 20 study locations across California, District of Columbia, Florida, Georgia, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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