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NCT06860724 · ClinicalTrials.gov registry record · NA
Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults
A NA study of Major Depressive Disorder, sponsored by University of Delaware.
- Recruiting
- Registry status
- NA
- Development phase
- 18
- Enrollment target
- 1
- Study location
NCT06860724: Recruiting NA study of Major Depressive Disorder, sponsored by University of Delaware.
NCT06860724 is a NA study of Major Depressive Disorder that is actively recruiting participants, run by University of Delaware. The registered enrollment target is 18 participants, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06860724, a NA study of Major Depressive Disorder, is actively recruiting participants, sponsored by University of Delaware.
- RECRUITING
- Registry status
- NA
- Development phase
- 18 participants
- Enrollment target
- 1
- Study location
Study Summary
The objective of this proposal is to determine whether heightened negative affective responsivity (NA-R) to daily stressors is related to blunted nitric oxide (NO)-mediated endothelium-dependent dilation (EDD) in working age adults and the extent to which this association is impacted by major depressive disorder (MDD).
Primary Outcome
A standard local heating protocol will be used to elicit EDD and the NO-dependent portion of this response will be determined pharmacologically (local perfusion of L-NAME). Vascular conductance will be calculated (CVC=flux/mean arterial pressure) and normalized to the site-specific maximum. NO-mediated EDD will be calculated as the percent change from the local heating-induced plateau to the post-L-NAME plateau.
Conditions Studied
Interventions
- OTHER NG-nitro-L-arginine methyl ester (L-NAME)
Study Locations (1)
Delaware
- University of Delaware - Newark
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2025-01-06 |
| Est. Completion | 2031-12-01 |
| Phase | NA |
What NCT06860724 shows while recruiting
NCT06860724 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Major Depressive Disorder appearing as the primary indexed condition, and to 1 intervention - of which NG-nitro-L-arginine methyl ester (L-NAME) is the first listed.
NCT06860724 reports a single indexed study location in Delaware.
Frequently Asked Questions
What is clinical trial NCT06860724 about?
NCT06860724 is a clinical study titled "Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults". The objective of this proposal is to determine whether heightened negative affective responsivity (NA-R) to daily stressors is related to blunted nitric oxide (NO)-mediated endothelium-dependent dilation (EDD) in working age adults and the extent to which this association is impacted by major depres...
What is the current status of trial NCT06860724?
This trial is currently recruiting. It is a NA study. The enrollment target is 18 participants. The study started on 2025-01-06. Estimated completion is 2031-12-01.
What conditions does trial NCT06860724 study?
This clinical trial studies the following conditions: Major Depressive Disorder.
What interventions are being tested in trial NCT06860724?
The interventions under investigation include: NG-nitro-L-arginine methyl ester (L-NAME) (OTHER).
Who is sponsoring clinical trial NCT06860724?
This trial is sponsored by University of Delaware, which has 106 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06860724 being conducted?
This trial has 1 study location across Delaware. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06860724's enrollment target sits among peer trials
18 250th of 282 higher than 30 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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