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NCT06835556 · ClinicalTrials.gov registry record · NA
Volatility in Paranoia (VIP) Trial: An RCT of Changes in Volatility With Psychotherapy
A NA study of Schizophrenia Disorders, sponsored by Vanderbilt University Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT06835556: Recruiting NA study of Schizophrenia Disorders, sponsored by Vanderbilt University Medical Center.
NCT06835556 is a NA study of Schizophrenia Disorders that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 120 participants, roughly in line with the 116-participant average among 5 other Schizophrenia Disorders trials with a reported enrollment target. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06835556, a NA study of Schizophrenia Disorders, is actively recruiting participants, sponsored by Vanderbilt University Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn whether learning and belief updating change in response to the treatment of persecutory delusions, in individuals with schizophrenia-spectrum disorders. The main questions are: 1. do prior expectations about environmental volatility reduce following effective psychotherapeutic treatment of delusions? 2. does corresponding brain activity related to volatility change with effective treatment of delusions? Participants will: 1. engage in CBTp or TAU + phone check-ins for 16 weeks 2. complete assessments at 4 timepoints over the course of 6 months 3. complete an MRI when possible
Primary Outcome
Reversal learning data will be collected from a 3-option probabilistic reversal learning task. This data will be analyzed using a computational model that estimates the prior expectations of environmental volatility. That parameter, in many models, is Mu3.
Conditions Studied
Interventions
- BEHAVIORAL Cognitive Behavioral Therapy
- BEHAVIORAL TAU
Study Locations (1)
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2025-01-15 |
| Est. Completion | 2030-02-01 |
| Phase | NA |
What NCT06835556 shows while recruiting
NCT06835556 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 116-participant average among 5 other Schizophrenia Disorders trials with a reported enrollment target.
The record links to 1 condition, with Schizophrenia Disorders appearing as the primary indexed condition, and to 2 interventions - of which Cognitive Behavioral Therapy is the first listed.
NCT06835556 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT06835556 about?
NCT06835556 is a clinical study titled "Volatility in Paranoia (VIP) Trial: An RCT of Changes in Volatility With Psychotherapy". The goal of this clinical trial is to learn whether learning and belief updating change in response to the treatment of persecutory delusions, in individuals with schizophrenia-spectrum disorders. The main questions are: 1. do prior expectations about environmental volatility reduce following effe...
What is the current status of trial NCT06835556?
This trial is currently recruiting. It is a NA study. The enrollment target is 120 participants. The study started on 2025-01-15. Estimated completion is 2030-02-01.
What conditions does trial NCT06835556 study?
This clinical trial studies the following conditions: Schizophrenia Disorders.
What interventions are being tested in trial NCT06835556?
The interventions under investigation include: Cognitive Behavioral Therapy (BEHAVIORAL), TAU (BEHAVIORAL).
Who is sponsoring clinical trial NCT06835556?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06835556 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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