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NCT07010614 · ClinicalTrials.gov registry record · NA
Brain Stimulation to the Hippocampus in Schizophrenia
A NA study of Mental Disorder and Schizophrenia Disorders, sponsored by Stanford University.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT07010614: Recruiting NA study of Mental Disorder and Schizophrenia Disorders, sponsored by Stanford University.
NCT07010614 is a NA study of Mental Disorder and Schizophrenia Disorders that is actively recruiting participants, run by Stanford University. The registered enrollment target is 60 participants, below the 322-participant average among 21 other Mental Disorder trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07010614, a NA study of Mental Disorder and Schizophrenia Disorders, is actively recruiting participants, sponsored by Stanford University.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
Schizophrenia - marked by delusions, hallucinations, and cognitive deficits - causes the most disability of any mental health condition, but existing treatments have significant side effect burden and are often ineffective. Disordered neural activity in the hippocampus likely contributes to schizophrenia symptoms, but to develop better therapies we need to understand whether hippocampal activity in schizophrenia can be systematically affected by non-invasive brain stimulation techniques like transcranial magnetic stimulation (TMS). This proposal will investigate the use of connectivity-guided theta burst brain stimulation to specifically target hippocampal function in schizophrenia, offering insights into fundamental hippocampal processes, schizophrenia pathophysiology, and potential avenues to use brain stimulation as a therapeutic tool in this devastating illness.
Primary Outcome
Change in spontaneous oscillatory EEG power from before to after application of one TBS session, for active and sham stimulation, as measured via intracranial recording electrodes (iEEG).
Conditions Studied
Interventions
- DEVICE TMS
- DEVICE Intracranial electrodes
- DEVICE TMS sham
Study Locations (1)
California
- Stanford University - Stanford
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-10-01 |
| Est. Completion | 2027-09-30 |
| Phase | NA |
What NCT07010614 shows while recruiting
NCT07010614 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 322-participant average among 21 other Mental Disorder trials with a reported enrollment target (81% lower).
The record links to 3 conditions, with Mental Disorder appearing as the primary indexed condition, and to 3 interventions - of which TMS is the first listed.
NCT07010614 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT07010614 about?
NCT07010614 is a clinical study titled "Brain Stimulation to the Hippocampus in Schizophrenia". Schizophrenia - marked by delusions, hallucinations, and cognitive deficits - causes the most disability of any mental health condition, but existing treatments have significant side effect burden and are often ineffective. Disordered neural activity in the hippocampus likely contributes to schizoph...
What is the current status of trial NCT07010614?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2025-10-01. Estimated completion is 2027-09-30.
What conditions does trial NCT07010614 study?
This clinical trial studies the following conditions: Mental Disorder, Schizophrenia Disorders, Psychotic Disorder.
What interventions are being tested in trial NCT07010614?
The interventions under investigation include: TMS (DEVICE), Intracranial electrodes (DEVICE), TMS sham (DEVICE).
Who is sponsoring clinical trial NCT07010614?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07010614 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mental Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07010614's enrollment target sits among peer trials
60 16th of 21 higher than 5 of 21 other Mental Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mental Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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