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NCT06834217 · ClinicalTrials.gov registry record · NA
Transcranial Direct Current Stimulation and Extinction in Obsessive Compulsive Disorder
A NA study of Obsessive Compulsive Disorder (OCD), sponsored by Yale University.
- Recruiting
- Registry status
- NA
- Development phase
- 180
- Enrollment target
- 1
- Study location
NCT06834217: Recruiting NA study of Obsessive Compulsive Disorder (OCD), sponsored by Yale University.
NCT06834217 is a NA study of Obsessive Compulsive Disorder (OCD) that is actively recruiting participants, run by Yale University. The registered enrollment target is 180 participants, below the 229-participant average among 12 other Obsessive Compulsive Disorder (OCD) trials with a reported enrollment target (21% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06834217, a NA study of Obsessive Compulsive Disorder (OCD), is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- NA
- Development phase
- 180 participants
- Enrollment target
- 1
- Study location
Study Summary
Obsessive-compulsive disorder (OCD) is associated with substantial impairments in quality of life and is among the most disabling psychiatric disorders. Exposure therapy is among the first-line of treatments for obsessive-compulsive disorder (OCD) . Extinction learning is thought to be a core mechanism of therapeutic exposure. Fear and safety signal learning are traditionally associated with activity and connectivity within the canonical corticolimbic "fear circuit", which includes the amygdala, medial prefrontal cortex (mPFC), and hippocampus. Transcranial direct current stimulation (tDCS) is a neuromodulation technology that can augment brain plasticity, learning, and memory. The proposed study will test if obsessive-compulsive disorder (OCD) is associated with inhibitory safety learning deficits and if transcranial direct current stimulation (tDCS) normalizes functional connectivity and safety signal processing to recover extinction deficits in obsessive-compulsive disorder (OCD).
Primary Outcome
Brain activity will be estimated with blood oxygen level-dependent (BOLD) response, which will be measured with magnetic resonance imaging (MRI).
Conditions Studied
Interventions
- DEVICE Sham transcranial direct current stimulation
- DEVICE Active transcranial direct current stimulation
Study Locations (1)
Connecticut
- Temple Medical Center - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2025-09-12 |
| Est. Completion | 2029-08-01 |
| Phase | NA |
What NCT06834217 shows while recruiting
NCT06834217 is an interventional study that assigns participants to a tested intervention. The registered 180 participants enrollment target is mid-sized for trials with a published cap, below the 229-participant average among 12 other Obsessive Compulsive Disorder (OCD) trials with a reported enrollment target (21% lower).
The record links to 1 condition, with Obsessive Compulsive Disorder (OCD) appearing as the primary indexed condition, and to 2 interventions - of which Sham transcranial direct current stimulation is the first listed.
NCT06834217 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT06834217 about?
NCT06834217 is a clinical study titled "Transcranial Direct Current Stimulation and Extinction in Obsessive Compulsive Disorder". Obsessive-compulsive disorder (OCD) is associated with substantial impairments in quality of life and is among the most disabling psychiatric disorders. Exposure therapy is among the first-line of treatments for obsessive-compulsive disorder (OCD) . Extinction learning is thought to be a core mechan...
What is the current status of trial NCT06834217?
This trial is currently recruiting. It is a NA study. The enrollment target is 180 participants. The study started on 2025-09-12. Estimated completion is 2029-08-01.
What conditions does trial NCT06834217 study?
This clinical trial studies the following conditions: Obsessive Compulsive Disorder (OCD).
What interventions are being tested in trial NCT06834217?
The interventions under investigation include: Sham transcranial direct current stimulation (DEVICE), Active transcranial direct current stimulation (DEVICE).
Who is sponsoring clinical trial NCT06834217?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06834217 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obsessive Compulsive Disorder (OCD)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06834217's enrollment target sits among peer trials
180 4th of 12 higher than 9 of 12 other Obsessive Compulsive Disorder (OCD) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obsessive Compulsive Disorder (OCD) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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