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ERP to Improve Functioning in Veterans With OCD
NCT05240924 · View on ClinicalTrials.gov ↗
Study Summary
Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no randomized controlled trials (RCTs) have examined the effectiveness of ERP among Veterans or individuals with both OCD and posttraumatic stress disorder (PTSD). This 4-year Hybrid Type I trial will compare outcomes of ERP to those of a control condition among Veterans with OCD. Primary and secondary aims will examine whether Veterans' functioning, quality of life, and OCD symptoms differ between the ERP and control in the full sample of Veterans with OCD, and in the half of the sample with both OCD and PTSD. The tertiary aim is to conduct a mixed-methods formative evaluation of the implementation potential of ERP in VA mental health settings.
Conditions Studied
Interventions
- BEHAVIORAL Exposure and Response Prevention
- OTHER Stress Management Training
Study Locations (18)
New York
- VA Western New York Healthcare System, Buffalo, NY — Buffalo
- VA NY Harbor Healthcare System, New York, NY — New York
- Northport VA Medical Center, Northport, NY — Northport
- James J. Peters VA Medical Center, Bronx, NY — The Bronx
North Carolina
- Asheville VA Medical Center, Asheville, NC — Asheville
- Durham VA Medical Center, Durham, NC — Durham
- Fayetteville VA Medical Center, Fayetteville, NC — Fayetteville
- Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC — Salisbury
Virginia
- Hampton VA Medical Center, Hampton, VA — Hampton
- Hunter Holmes McGuire VA Medical Center, Richmond, VA — Richmond
- Salem VA Medical Center, Salem, VA — Salem
Oregon
- VA Roseburg Healthcare System, Roseburg, OR — Roseburg
- VA Southern Oregon Rehabilitation Center and Clinics, White City, OR — White City
Washington
- Spokane VA Medical Center, Spokane, WA — Spokane
- Jonathan M. Wainwright Memorial VA Medical Center, Walla Walla, WA — Walla Walla
New Jersey
- East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ — East Orange
South Carolina
- Ralph H. Johnson VA Medical Center, Charleston, SC — Charleston
Texas
- Michael E. DeBakey VA Medical Center, Houston, TX — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2022-10-03 |
| Est. Completion | 2026-05-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05240924
The ClinicalTrials.gov registry entry for NCT05240924 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 160 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is VA Office of Research and Development, which has 1,863 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Obsessive Compulsive Disorder (OCD) appearing as the primary indexed condition, and to 2 interventions — of which Exposure and Response Prevention is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05240924 reports 18 study locations spanning 8 distinct geographic areas — top geographies include New York, North Carolina, Virginia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05240924 about?
NCT05240924 is a clinical study titled "ERP to Improve Functioning in Veterans With OCD". Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no randomized controlled trials (RCTs) have examined the effectiveness of ERP am...
What is the current status of trial NCT05240924?
This trial is currently recruiting. It is a NA study. The enrollment target is 160 participants. The study started on 2022-10-03. Estimated completion is 2026-05-31.
What conditions does trial NCT05240924 study?
This clinical trial studies the following conditions: Obsessive Compulsive Disorder (OCD), Comorbid Post-Traumatic Stress Disorder and OCD. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05240924?
The interventions under investigation include: Exposure and Response Prevention (BEHAVIORAL), Stress Management Training (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05240924?
This trial is sponsored by VA Office of Research and Development, which has 1,863 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05240924 being conducted?
This trial has 18 study locations across New Jersey, New York, North Carolina, Oregon, South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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