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NCT06823453 · ClinicalTrials.gov registry record · NA
Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions
A NA study of People Who Use Opioids/People With Opioid Use Disorder (OUD) and Opioid Overdose Prevention, sponsored by University of Illinois at Chicago.
- Recruiting
- Registry status
- NA
- Development phase
- 600
- Enrollment target
- 1
- Study location
NCT06823453: Recruiting NA study of People Who Use Opioids/People With Opioid Use Disorder (OUD) and Opioid Overdose Prevention, sponsored by University of Illinois at Chicago.
NCT06823453 is a NA study of People Who Use Opioids/People With Opioid Use Disorder (OUD) and Opioid Overdose Prevention that is actively recruiting participants, run by University of Illinois at Chicago. The registered enrollment target is 600 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (57% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06823453, a NA study of People Who Use Opioids/People With Opioid Use Disorder (OUD) and Opioid Overdose Prevention, is actively recruiting participants, sponsored by University of Illinois at Chicago.
- RECRUITING
- Registry status
- NA
- Development phase
- 600 participants
- Enrollment target
- 1
- Study location
Study Summary
Fatal opioid overdoses are more frequent among populations with low access to harm reduction (HR) services and with high substance use-related stigma (which is a major barrier to accessing HR services). One such population is older adults who use drugs (PWUD) on the West side of Chicago. Over 34% of Chicago's opioid-related EMS responses in 2023 were located in communities on the West side, but older adults in these communities access HR services at low rates, likely due to stigma and other barriers. To help address these barriers and increase HR service access among this population, the proposed clinical trial will evaluate a novel intervention that will recruit non-substance-using friends and family members of people who use opioids and live on the West side of Chicago, educate them on HR tools and services, and train them to become peer HR support champions. They will be asked to recruit one friend or family member who uses opioids to the study, who will also be provided with an educational training on overdose risk reduction and available HR tools and services. The intervention will then facilitate a counselor-led initial conversation between peer HR support champions and their friend or family member who uses opioids to help establish HR support, and provide all participants with naloxone and fentanyl test strip kits. This intervention will not only provide another mechanism through which PWUD can access HR tools and services, thereby reducing logistical barriers, but should also reduce stigma and increase social support by facilitating and normalizing open conversations about HR between PWUD and their non-PWUD HR support champions. Participants of a previous focus group conducted by the Investigators among West side PWUD thought this intervention would be helpful, said they would be willing to participate in it, and said they knew someone who could participate as their non-PWUD peer HR support champion. To facilitate recruitment of older adults, the Investigat
Primary Outcome
Overdose frequency and experiences will be measured using participant self-report on items used by the Investigators in previous studies of PWUD. Items will ask about the number of overdoses participants experienced in the last three months (at baseline) and since the last interview (for follow-up). For each overdose reported, items will ask whether the participant was alone, whether naloxone was used, whether first responders were called, and whether an emergency room visit occurred. Participan
Conditions Studied
Interventions
- BEHAVIORAL Peer Harm Reduction Support Champion Intervention
Study Locations (1)
Illinois
- Community Outreach Intervention Projects (COIP) - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 2025-10-28 |
| Est. Completion | 2028-09-01 |
| Phase | NA |
What NCT06823453 shows while recruiting
NCT06823453 is an interventional study that assigns participants to a tested intervention. The registered 600 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (57% lower).
The record links to 5 conditions, with People Who Use Opioids/People With Opioid Use Disorder (OUD) appearing as the primary indexed condition, and to 1 intervention - of which Peer Harm Reduction Support Champion Intervention is the first listed.
NCT06823453 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT06823453 about?
NCT06823453 is a clinical study titled "Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions". Fatal opioid overdoses are more frequent among populations with low access to harm reduction (HR) services and with high substance use-related stigma (which is a major barrier to accessing HR services). One such population is older adults who use drugs (PWUD) on the West side of Chicago. Over 34% of...
What is the current status of trial NCT06823453?
This trial is currently recruiting. It is a NA study. The enrollment target is 600 participants. The study started on 2025-10-28. Estimated completion is 2028-09-01.
What conditions does trial NCT06823453 study?
This clinical trial studies the following conditions: People Who Use Opioids/People With Opioid Use Disorder (OUD), Opioid Overdose Prevention, Reduction of Substance Use-related Stigma, Non-substance-using People With a Friend or Family Member Who Uses Opioids, Peer Harm Reduction Support Champions.
What interventions are being tested in trial NCT06823453?
The interventions under investigation include: Peer Harm Reduction Support Champion Intervention (BEHAVIORAL).
Who is sponsoring clinical trial NCT06823453?
This trial is sponsored by University of Illinois at Chicago, which has 430 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06823453 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Where NCT06823453's enrollment target sits among peer trials
600 162nd of 2000 higher than 1,828 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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