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BMS-986489 (Atigotatug + Nivolumab) vs Durvalumab in Limited-stage Small-cell Lung Cancer (TIGOS-LS)
NCT06773910 · View on ClinicalTrials.gov ↗
Study Summary
This is an open-label, randomized study of BMS-986489 (atigotatug + nivolumab fixed-dose combination) vs durvalumab in limited-stage (LS)-small-cell lung cancer (SCLC) participants. The main goals of this study are to: * Evaluate the efficacy of BMS-986489 vs durvalumab * Evaluate the safety profile of BMS-986489
Conditions Studied
Interventions
- DRUG Durvalumab
- DRUG BMS-986489
Study Locations (20)
Florida
- Florida Cancer Specialists - South — Fort Myers
- University of Miami - Sylvester Cancer Center — Miami
- Ocala Oncology Center — Ocala
- Florida Cancer Specialists - North — Orange City
- Cancer Care Centers of Brevard — Palm Bay
- Florida Cancer Specialists - East — West Palm Beach
Illinois
- Illinois Cancer Specialists — Arlington Heights
- Illinois Cancer Care — Peoria
Kentucky
- Baptist Health - Lexington — Lexington
- Baptist Health - Louisville — Louisville
Ohio
- Oncology Hematology Care — Cincinnati
- Mid Ohio Hem/ Onc dba The Mark H Zangmeister Center — Columbus
Alabama
- Southern Cancer Center — Daphne
California
- Sansum Clinic — Santa Barbara
Indiana
- Indiana University Simon Cancer Center — Indianapolis
Minnesota
- Minnesota Oncology Hematology — Maple Grove
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2025-03-11 |
| Est. Completion | 2032-09 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06773910
The ClinicalTrials.gov registry entry for NCT06773910 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 250 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is SCRI Development Innovations, which has 63 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Limited Stage Small Cell Lung Cancer appearing as the primary indexed condition, and to 2 interventions — of which Durvalumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06773910 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Florida, Illinois, Kentucky. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06773910 about?
NCT06773910 is a clinical study titled "BMS-986489 (Atigotatug + Nivolumab) vs Durvalumab in Limited-stage Small-cell Lung Cancer (TIGOS-LS)". This is an open-label, randomized study of BMS-986489 (atigotatug + nivolumab fixed-dose combination) vs durvalumab in limited-stage (LS)-small-cell lung cancer (SCLC) participants. The main goals of this study are to: * Evaluate the efficacy of BMS-986489 vs durvalumab * Evaluate the safety profi...
What is the current status of trial NCT06773910?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 250 participants. The study started on 2025-03-11. Estimated completion is 2032-09.
What conditions does trial NCT06773910 study?
This clinical trial studies the following conditions: Limited Stage Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06773910?
The interventions under investigation include: Durvalumab (DRUG), BMS-986489 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06773910?
This trial is sponsored by SCRI Development Innovations, which has 63 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06773910 being conducted?
This trial has 20 study locations across Alabama, California, Florida, Illinois, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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