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NCT04276870 · ClinicalTrials.gov registry record · Phase 2
Orphan Indications for CD19 Redirected Autologous T Cells
A Phase 2 study of Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALL and Infants With Very High Risk KMT2A B-ALL, sponsored by Stephan Grupp MD PhD.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 133
- Enrollment target
- 1
- Study location
NCT04276870 is a Phase 2 study of Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALL and Infants With Very High Risk KMT2A B-ALL that is actively recruiting participants, run by Stephan Grupp MD PhD. The registered enrollment target is 133 participants. The trial reports 1 study location across 1 state.
The verdict
NCT04276870, a Phase 2 study of Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALL and Infants With Very High Risk KMT2A B-ALL, is actively recruiting participants, sponsored by Stephan Grupp MD PhD.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 133 participants
- Enrollment target
- 1
- Study location
Study Summary
This is an open-label, four-cohort, phase 2 study to determine the efficacy of CART19 in pediatric and young adult patientswith hypodiploid (Cohort A) or t(17;19) B-ALL (Cohort B), infants with very high risk KMT2A B-ALL (Cohort C), and in patients with central nervous system (CNS) relapse who did not receive cranial radiation (XRT) or bone marrow transplantation (BMT) (Cohort D).
Conditions Studied
Interventions
- BIOLOGICAL Murine CART19
Study Locations (1)
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 133 participants |
| Start Date | 2020-03-12 |
| Est. Completion | 2037-03-10 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04276870
The ClinicalTrials.gov registry entry for NCT04276870 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 133 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Stephan Grupp MD PhD, which has 8 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALL appearing as the primary indexed condition, and to 1 intervention - of which Murine CART19 is the first listed.
NCT04276870 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04276870 about?
NCT04276870 is a clinical study titled "Orphan Indications for CD19 Redirected Autologous T Cells". This is an open-label, four-cohort, phase 2 study to determine the efficacy of CART19 in pediatric and young adult patientswith hypodiploid (Cohort A) or t(17;19) B-ALL (Cohort B), infants with very high risk KMT2A B-ALL (Cohort C), and in patients with central nervous system (CNS) relapse who did n...
What is the current status of trial NCT04276870?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 133 participants. The study started on 2020-03-12. Estimated completion is 2037-03-10.
What conditions does trial NCT04276870 study?
This clinical trial studies the following conditions: Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALL, Infants With Very High Risk KMT2A B-ALL, Patients With Central Nervous System Relapse Who Did Not Receive Cranial Radiation or Bone Marrow Transplantation.
What interventions are being tested in trial NCT04276870?
The interventions under investigation include: Murine CART19 (BIOLOGICAL).
Who is sponsoring clinical trial NCT04276870?
This trial is sponsored by Stephan Grupp MD PhD, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04276870 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALL
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Infants With Very High Risk KMT2A B-ALL
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Pennsylvania
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