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NCT06719557 · ClinicalTrials.gov registry record · Phase 1
A Study of the Effect of Itraconazole and Phenytoin on Calderasib (MK-1084) in Healthy Adults (MK-1084-008)
A Phase 1 study of Healthy, sponsored by Merck Sharp & Dohme.
- Completed
- Registry status
- Phase 1
- Development phase
- 28
- Enrollment target
- 1
- Study location
NCT06719557: Completed Phase 1 study of Healthy, sponsored by Merck Sharp & Dohme.
NCT06719557 is a Phase 1 study of Healthy that has completed, run by Merck Sharp & Dohme. The registered enrollment target is 28 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06719557, a Phase 1 study of Healthy, has completed, sponsored by Merck Sharp & Dohme.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 28 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this study is to learn what happens to calderasib in a healthy person's body over time, called a pharmacokinetic (PK) study. Researchers want to compare the amount of calderasib when it is taken as a single dose; with multiple doses of itraconazole, or with multiple doses of phenytoin.
Primary Outcome
Blood samples will be collected to determine the AUC0-Inf of calderasib.
Conditions Studied
Interventions
- DRUG Calderasib
- DRUG Itraconazole
- DRUG Phenytoin
Study Locations (1)
Nebraska
- Celerion (Site 0001) - Lincoln
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2024-05-20 |
| Est. Completion | 2024-07-30 |
| Phase | Phase 1 |
What the finished NCT06719557 record still lists
NCT06719557 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 28 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 3 interventions - of which Calderasib is the first listed.
NCT06719557 reports a single indexed study location in Nebraska.
Frequently Asked Questions
What is clinical trial NCT06719557 about?
NCT06719557 is a clinical study titled "A Study of the Effect of Itraconazole and Phenytoin on Calderasib (MK-1084) in Healthy Adults (MK-1084-008)". The goal of this study is to learn what happens to calderasib in a healthy person's body over time, called a pharmacokinetic (PK) study. Researchers want to compare the amount of calderasib when it is taken as a single dose; with multiple doses of itraconazole, or with multiple doses of phenytoin.
What is the current status of trial NCT06719557?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 28 participants. The study started on 2024-05-20. Estimated completion is 2024-07-30.
What conditions does trial NCT06719557 study?
This clinical trial studies the following conditions: Healthy.
What interventions are being tested in trial NCT06719557?
The interventions under investigation include: Calderasib (DRUG), Itraconazole (DRUG), Phenytoin (DRUG).
Who is sponsoring clinical trial NCT06719557?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06719557 being conducted?
This trial has 1 study location across Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06719557's enrollment target sits among peer trials
28 736th of 1090 higher than 340 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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