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NCT06512935 · ClinicalTrials.gov registry record · NA
Ventilator Pressure and Optimization of Compliance and Hemodynamics
A NA study of Bronchopulmonary Dysplasia and Extreme Prematurity, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- NA
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT06512935 is a NA study of Bronchopulmonary Dysplasia and Extreme Prematurity that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 24 participants, below the 235-participant average among 29 other Bronchopulmonary Dysplasia trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06512935, a NA study of Bronchopulmonary Dysplasia and Extreme Prematurity, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- NA
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
In preterm infants \< 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and improve oxygenation. This study may emphasize using point-of-care echocardiography along with electrical impedance tomography (EIT) to optimize ventilator settings in preterm infants. Infants will be randomized to a 4-hour crossover period of increasing and decreasing PEEP in random order from baseline to determine compliance, oxygenation, and cardiac hemodynamics at each step using echocardiography (ECHO) and EIT measurements. There will be a 15-minute washout period after changes prior to data collection.
Conditions Studied
Interventions
- OTHER Increase in the PEEP followed by decrease in the PEEP
- OTHER Decrease in the PEEP followed by increase in the PEEP
Study Locations (1)
Alabama
- Univerisity of Alabama - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2025-08-01 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06512935
The ClinicalTrials.gov registry entry for NCT06512935 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 235-participant average among 29 other Bronchopulmonary Dysplasia trials with a reported enrollment target (90% lower). The listed sponsor is University of Alabama at Birmingham, which has 1,160 total studies on file at ClinicalTrials.gov.
The record links to 5 conditions, with Bronchopulmonary Dysplasia appearing as the primary indexed condition, and to 2 interventions - of which Increase in the PEEP followed by decrease in the PEEP is the first listed.
NCT06512935 reports 1 study location spanning 1 distinct geographic area - top geographies include Alabama.
Frequently Asked Questions
What is clinical trial NCT06512935 about?
NCT06512935 is a clinical study titled "Ventilator Pressure and Optimization of Compliance and Hemodynamics". In preterm infants \< 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and improve oxygenation. This study may emphasize using point-of-care echocard...
What is the current status of trial NCT06512935?
This trial is currently recruiting. It is a NA study. The enrollment target is 24 participants. The study started on 2025-08-01. Estimated completion is 2026-06-30.
What conditions does trial NCT06512935 study?
This clinical trial studies the following conditions: Bronchopulmonary Dysplasia, Extreme Prematurity, Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Ventilator Lung; Newborn, Ventilation Perfusion Mismatch.
What interventions are being tested in trial NCT06512935?
The interventions under investigation include: Increase in the PEEP followed by decrease in the PEEP (OTHER), Decrease in the PEEP followed by increase in the PEEP (OTHER).
Who is sponsoring clinical trial NCT06512935?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06512935 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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